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ENZYME

ENZYME entry: EC 3.2.1.114

PURL: https://purl.expasy.org/enzyme/EC/3.2.1.114
Accepted Name
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Alternative Name(s)
ManII
mannosidase II
Reaction catalysed
N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
Comment(s)
  • The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus.
  • It removes two mannosyl residues, one linked by alpha1,3 linkage, and the other linked by alpha1,6 linkage, both of which are removed by the same catalytic site.
  • The enzyme is sensitive to swainsonine.
Cross-references
BRENDA3.2.1.114
EC2PDB3.2.1.114
ExplorEnz3.2.1.114
KEGG Ligand Database for Enzyme Nomenclature3.2.1.114
IUBMB Enzyme Nomenclature3.2.1.114
MEDLINEFind literature relating to 3.2.1.114
MetaCyc3.2.1.114
Rhea expert-curated reactions3.2.1.114
UniProtKB/Swiss-Prot
Q9LFR0, GMAN2_ARATHQ16706, MA2A1_HUMANP27046, MA2A1_MOUSE
P28494, MA2A1_RATP49641, MA2A2_HUMANQ8BRK9, MA2A2_MOUSE
Q24451, MAN2_DROMEO18497, MAN2_SPOFR

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
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