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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.2.1.114

Accepted Name
Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase.
Alternative Name(s)
ManII.
Mannosidase II.
Reaction catalysed
Man(5)GlcNAc(3)-[protein] + 2 H(2)O <=> Man(3)GlcNAc(3)-[protein] + 2 alpha-D-mannopyranose
Comment(s)
  • The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus.
  • It removes two mannosyl residues, one linked by alpha-1,3 linkage, and the other linked by alpha-1,6 linkage, both of which are removed by the same catalytic site.
  • The enzyme is sensitive to swainsonine.
Cross-references
BRENDA3.2.1.114
EC2PDB3.2.1.114
ExplorEnz3.2.1.114
PRIAM enzyme-specific profiles3.2.1.114
KEGG Ligand Database for Enzyme Nomenclature3.2.1.114
IUBMB Enzyme Nomenclature3.2.1.114
IntEnz3.2.1.114
MEDLINEFind literature relating to 3.2.1.114
MetaCyc3.2.1.114
UniProtKB/Swiss-Prot
Q9LFR0, GMAN2_ARATH;  Q16706, MA2A1_HUMAN;  P27046, MA2A1_MOUSE;  
P28494, MA2A1_RAT;  P49641, MA2A2_HUMAN;  Q8BRK9, MA2A2_MOUSE;  
Q24451, MAN2_DROME;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-