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ENZYME entry: EC 2.4.1.152

Accepted Name
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase.
Alternative Name(s)
Galactoside 3-fucosyltransferase.
GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L- fucosyltransferase.
Guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase.
Lewis-negative alpha-3-fucosyltransferase.
Plasma alpha-3-fucosyltransferase.
Reaction catalysed
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R <=> GDP + beta-D-galactosyl-(1->4)-(alpha-L-fucosyl-(1->3))-N-acetyl-D-glucosaminyl-R
Comment(s)
  • Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid.
  • This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
Cross-references
BRENDA2.4.1.152
EC2PDB2.4.1.152
ExplorEnz2.4.1.152
PRIAM enzyme-specific profiles2.4.1.152
KEGG Ligand Database for Enzyme Nomenclature2.4.1.152
IUBMB Enzyme Nomenclature2.4.1.152
IntEnz2.4.1.152
MEDLINEFind literature relating to 2.4.1.152
MetaCyc2.4.1.152
Rhea expert-curated reactions2.4.1.152
UniProtKB/Swiss-Prot
O30511, FUCT_HELPX;  Q8HYJ7, FUT5_GORGO;  Q11128, FUT5_HUMAN;  
Q8HYJ3, FUT5_HYLLA;  P56433, FUT5_PANTR;  Q8HYJ4, FUT5_PONPY;  
Q8HYJ6, FUT6_GORGO;  P51993, FUT6_HUMAN;  P56434, FUT6_PANTR;  
Q9GKU6, FUT6_PONPY;  Q8HZR2, FUT9_BOVIN;  Q659L1, FUT9_CANLF;  
Q9JIG1, FUT9_CRIGR;  Q9Y231, FUT9_HUMAN;  O88819, FUT9_MOUSE;  
Q659L0, FUT9_PANTR;  Q99JB3, FUT9_RAT;  

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