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ENZYME entry: EC 2.4.1.152

Accepted Name
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase.
Alternative Name(s)
Galactoside 3-fucosyltransferase.
GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L- fucosyltransferase.
Guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase.
Lewis-negative alpha-3-fucosyltransferase.
Plasma alpha-3-fucosyltransferase.
Reaction catalysed
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R <=> GDP + beta-D-galactosyl-(1->4)-(alpha-L-fucosyl-(1->3))-N-acetyl-D-glucosaminyl-R
Comment(s)
  • Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid.
  • This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
Cross-references
BRENDA2.4.1.152
EC2PDB2.4.1.152
ExplorEnz2.4.1.152
PRIAM enzyme-specific profiles2.4.1.152
KEGG Ligand Database for Enzyme Nomenclature2.4.1.152
IUBMB Enzyme Nomenclature2.4.1.152
IntEnz2.4.1.152
MEDLINEFind literature relating to 2.4.1.152
MetaCyc2.4.1.152
UniProtKB/Swiss-Prot
O30511, FUCT_HELPX

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