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ENZYME

ENZYME entry: EC 2.4.1.152

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.152
Accepted Name
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
Alternative Name(s)
galactoside 3-fucosyltransferase
GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L- fucosyltransferase
guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase
Lewis-negative alpha-3-fucosyltransferase
plasma alpha-3-fucosyltransferase
Reaction catalysed
a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)
Comment(s)
  • Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid.
  • This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
Cross-references
BRENDA2.4.1.152
EC2PDB2.4.1.152
ExplorEnz2.4.1.152
KEGG Ligand Database for Enzyme Nomenclature2.4.1.152
IUBMB Enzyme Nomenclature2.4.1.152
MEDLINEFind literature relating to 2.4.1.152
MetaCyc2.4.1.152
Rhea expert-curated reactions2.4.1.152
UniProtKB/Swiss-Prot
O30511, FUCT_HELPXQ11126, FUT3_BOVINP21217, FUT3_HUMAN
O19058, FUT3_PANTRQ8HYJ5, FUT3_PONPYQ8HZR3, FUT4_BOVIN
P22083, FUT4_HUMANQ11127, FUT4_MOUSEQ659K9, FUT4_PANTR
Q62994, FUT4_RATQ8HYJ7, FUT5_GORGOQ11128, FUT5_HUMAN
Q8HYJ3, FUT5_HYLLAP56433, FUT5_PANTRQ8HYJ4, FUT5_PONPY
Q8HYJ6, FUT6_GORGOP51993, FUT6_HUMANP56434, FUT6_PANTR
Q9GKU6, FUT6_PONPYQ8HZR2, FUT9_BOVINQ659L1, FUT9_CANLF
Q9JIG1, FUT9_CRIGRQ9Y231, FUT9_HUMANO88819, FUT9_MOUSE
Q659L0, FUT9_PANTRQ99JB3, FUT9_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-