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ENZYME entry: EC 2.4.1.152

Accepted Name
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase.
Alternative Name(s)
galactoside 3-fucosyltransferase.
GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L- fucosyltransferase.
guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase.
Lewis-negative alpha-3-fucosyltransferase.
plasma alpha-3-fucosyltransferase.
Reaction catalysed
a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)
Comment(s)
  • Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid.
  • This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
Cross-references
BRENDA2.4.1.152
EC2PDB2.4.1.152
ExplorEnz2.4.1.152
PRIAM enzyme-specific profiles2.4.1.152
KEGG Ligand Database for Enzyme Nomenclature2.4.1.152
IUBMB Enzyme Nomenclature2.4.1.152
IntEnz2.4.1.152
MEDLINEFind literature relating to 2.4.1.152
MetaCyc2.4.1.152
Rhea expert-curated reactions2.4.1.152
UniProtKB/Swiss-Prot
O30511, FUCT_HELPX;  Q11126, FUT3_BOVIN;  P21217, FUT3_HUMAN;  
O19058, FUT3_PANTR;  Q8HYJ5, FUT3_PONPY;  Q8HZR3, FUT4_BOVIN;  
P22083, FUT4_HUMAN;  Q11127, FUT4_MOUSE;  Q659K9, FUT4_PANTR;  
Q62994, FUT4_RAT;  Q8HYJ7, FUT5_GORGO;  Q11128, FUT5_HUMAN;  
Q8HYJ3, FUT5_HYLLA;  P56433, FUT5_PANTR;  Q8HYJ4, FUT5_PONPY;  
Q8HYJ6, FUT6_GORGO;  P51993, FUT6_HUMAN;  P56434, FUT6_PANTR;  
Q9GKU6, FUT6_PONPY;  Q8HZR2, FUT9_BOVIN;  Q659L1, FUT9_CANLF;  
Q9JIG1, FUT9_CRIGR;  Q9Y231, FUT9_HUMAN;  O88819, FUT9_MOUSE;  
Q659L0, FUT9_PANTR;  Q99JB3, FUT9_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
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