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ENZYME

ENZYME entry: EC 2.4.1.65

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.65
Accepted Name
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
Alternative Name(s)
(Le(a))-dependent (alpha-3/4)-fucosyltransferase
alpha(1,3/1,4) fucosyltransferase III
alpha-(1->4)-L-fucosyltransferase
alpha-4-L-fucosyltransferase
beta-acetylglucosaminylsaccharide fucosyltransferase
blood group Lewis alpha-4-fucosyltransferase
blood-group substance Le(a)-dependent fucosyltransferase
FucT-II
galactoside 3(4)-L-fucosyltransferase
guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L- fucosyltransferase
guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase
guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase
Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase
Lewis alpha-(1->3/4)-fucosyltransferase
Lewis blood group alpha-(1->3/4)-fucosyltransferase
Lewis FT
Reaction catalysed
a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)
Comment(s)
  • Product of the Lewis blood group gene.
  • Normally acts on a glycoconjugate where R (see CA line) is a glycoprotein or glycolipid.
  • Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity toward the glucose residue in free lactose.
  • Fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152 which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4.
  • Enzymes catalyzing the 4-alpha-fucosylation of the GlcNAc in beta-D- Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha- fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans.
  • In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase activities.
Cross-references
BRENDA2.4.1.65
EC2PDB2.4.1.65
ExplorEnz2.4.1.65
KEGG Ligand Database for Enzyme Nomenclature2.4.1.65
IUBMB Enzyme Nomenclature2.4.1.65
MEDLINEFind literature relating to 2.4.1.65
MetaCyc2.4.1.65
Rhea expert-curated reactions2.4.1.65
UniProtKB/Swiss-Prot
Q11126, FUT3_BOVINP21217, FUT3_HUMANO19058, FUT3_PANTR
Q8HYJ5, FUT3_PONPYQ8HYJ7, FUT5_GORGOQ11128, FUT5_HUMAN
Q8HYJ3, FUT5_HYLLAP56433, FUT5_PANTRQ8HYJ4, FUT5_PONPY
G5EFP5, FUTC_CAEELG5EE06, FUTD_CAEEL

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