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| Accepted Name |
|---|
| 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase.
|
| Alternative Name(s) |
|---|
| (Le(a))-dependent (alpha-3/4)-fucosyltransferase. |
| alpha(1,3/1,4) fucosyltransferase III. |
| alpha-(1->4)-L-fucosyltransferase. |
| alpha-4-L-fucosyltransferase. |
| beta-acetylglucosaminylsaccharide fucosyltransferase. |
| blood group Lewis alpha-4-fucosyltransferase. |
| blood-group substance Le(a)-dependent fucosyltransferase. |
| FucT-II. |
| galactoside 3(4)-L-fucosyltransferase. |
| guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-
fucosyltransferase. |
| guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase. |
| guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase. |
| Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase. |
| Lewis alpha-(1->3/4)-fucosyltransferase. |
| Lewis blood group alpha-(1->3/4)-fucosyltransferase. |
| Lewis FT. |
| Reaction catalysed |
|---|
| a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) |
| Comment(s) |
|---|
- Product of the Lewis blood group gene.
- Normally acts on a glycoconjugate where R (see CA line) is a
glycoprotein or glycolipid.
- Although it is a 4-fucosyltransferase, it has a persistent
3-fucosyltransferase activity toward the glucose residue in free
lactose.
- Fucosylates on O-4 of an N-acetylglucosamine that carries a
galactosyl group on O-3, unlike EC 2.4.1.152 which fucosylates on O-3
of an N-acetylglucosamine that carries a galactosyl group on O-4.
- Enzymes catalyzing the 4-alpha-fucosylation of the GlcNAc in beta-D-
Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha-
fucosyltransferases) are present in plants, where the function in
vivo is the modification of N-glycans.
- In addition, the fucTa gene of Helicobacter strain UA948 encodes a
fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase
activities.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.65 |
| EC2PDB | 2.4.1.65 |
| ExplorEnz | 2.4.1.65 |
| PRIAM enzyme-specific profiles | 2.4.1.65 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.65 |
| IUBMB Enzyme Nomenclature | 2.4.1.65 |
| IntEnz | 2.4.1.65 |
| MEDLINE | Find literature relating to 2.4.1.65 |
| MetaCyc | 2.4.1.65 |
| Rhea expert-curated reactions | 2.4.1.65 |
| UniProtKB/Swiss-Prot |
| Q11126, FUT3_BOVIN; | P21217, FUT3_HUMAN; | O19058, FUT3_PANTR; |
| Q8HYJ5, FUT3_PONPY; | Q8HYJ7, FUT5_GORGO; | Q11128, FUT5_HUMAN; |
| Q8HYJ3, FUT5_HYLLA; | P56433, FUT5_PANTR; | Q8HYJ4, FUT5_PONPY; |
| G5EFP5, FUTC_CAEEL; | G5EE06, FUTD_CAEEL; |
|