ENZYME entry: EC 2.4.1.174
Accepted Name |
Glucuronylgalactosylproteoglycan 4-beta-N-
acetylgalactosaminyltransferase.
|
Alternative Name(s) |
Glucuronylgalactosylproteoglycan beta-1,4-N-
acetylgalactosaminyltransferase. |
N-acetylgalactosaminyltransferase I. |
Uridine diphosphoacetylgalactosamine-chondroitin
acetylgalactosaminyltransferase I. |
Reaction catalysed |
UDP-N-acetyl-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine <=> UDP + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine |
Comment(s) |
- Involved in the biosynthesis of chondroitin sulfate.
- Key enzyme activity for the initiation of chondroitin and dermatan
sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core.
|
Cross-references |
BRENDA | 2.4.1.174 |
EC2PDB | 2.4.1.174 |
ExplorEnz | 2.4.1.174 |
PRIAM enzyme-specific profiles | 2.4.1.174 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.174 |
IUBMB Enzyme Nomenclature | 2.4.1.174 |
IntEnz | 2.4.1.174 |
MEDLINE | Find literature relating to 2.4.1.174 |
MetaCyc | 2.4.1.174 |
UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-