ENZYME entry: EC 2.4.1.174

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.174

Accepted Name

glucuronylgalactosylproteoglycan 4-beta-N- acetylgalactosaminyltransferase

Alternative Name(s)

glucuronylgalactosylproteoglycan beta-1,4-N- acetylgalactosaminyltransferase

N-acetylgalactosaminyltransferase I

uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I

Reaction catalysed

3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)

Comment(s)

Involved in the biosynthesis of chondroitin sulfate.
Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core.

Cross-references

Rhea expert-curated reactions

2.4.1.174

ExplorEnz

2.4.1.174

IUBMB Enzyme Nomenclature

2.4.1.174

UniProtKB/Swiss-Prot

Q8TDX6, CGAT1_HUMAN	Q8BJQ9, CGAT1_MOUSE	Q8N6G5, CGAT2_HUMAN
Q8C1F4, CGAT2_MOUSE	Q7Z1Z1, CHSSA_CAEEL

BRENDA

2.4.1.174

MetaCyc

2.4.1.174

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.174

EC2PDB

2.4.1.174

MEDLINE

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-