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ENZYME entry: EC 2.4.1.174

Accepted Name
glucuronylgalactosylproteoglycan 4-beta-N- acetylgalactosaminyltransferase.
Alternative Name(s)
glucuronylgalactosylproteoglycan beta-1,4-N- acetylgalactosaminyltransferase.
N-acetylgalactosaminyltransferase I.
uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I.
Reaction catalysed
3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
Comment(s)
  • Involved in the biosynthesis of chondroitin sulfate.
  • Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core.
Cross-references
BRENDA2.4.1.174
EC2PDB2.4.1.174
ExplorEnz2.4.1.174
PRIAM enzyme-specific profiles2.4.1.174
KEGG Ligand Database for Enzyme Nomenclature2.4.1.174
IUBMB Enzyme Nomenclature2.4.1.174
IntEnz2.4.1.174
MEDLINEFind literature relating to 2.4.1.174
MetaCyc2.4.1.174
Rhea expert-curated reactions2.4.1.174
UniProtKB/Swiss-Prot
Q8TDX6, CGAT1_HUMAN;  Q8BJQ9, CGAT1_MOUSE;  Q8N6G5, CGAT2_HUMAN;  
Q8C1F4, CGAT2_MOUSE;  Q7Z1Z1, CHSSA_CAEEL;  

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