ENZYME entry: EC 2.4.1.174

Accepted Name

Glucuronylgalactosylproteoglycan 4-beta-N- acetylgalactosaminyltransferase.

Alternative Name(s)

Glucuronylgalactosylproteoglycan beta-1,4-N- acetylgalactosaminyltransferase.

N-acetylgalactosaminyltransferase I.

Uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I.

Reaction catalysed

UDP-N-acetyl-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine <=> UDP + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Comment(s)

Involved in the biosynthesis of chondroitin sulfate.
Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core.

Cross-references

BRENDA

2.4.1.174

EC2PDB

2.4.1.174

ExplorEnz

2.4.1.174

PRIAM enzyme-specific profiles

2.4.1.174

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.174

IUBMB Enzyme Nomenclature

2.4.1.174

IntEnz

2.4.1.174

MEDLINE

Find literature relating to 2.4.1.174

MetaCyc

2.4.1.174

UniProtKB/Swiss-Prot

Q8TDX6, CGAT1_HUMAN;	Q8BJQ9, CGAT1_MOUSE;	Q8N6G5, CGAT2_HUMAN;
Q8C1F4, CGAT2_MOUSE;	Q7Z1Z1, CHSSA_CAEEL;

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
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