Home  |  Contact

ENZYME entry: EC 2.4.1.212

Accepted Name
hyaluronan synthase.
Alternative Name(s)
HAS.
Reaction catalysed
  • [hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP
  • N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate <=> [hyaluronan](n+1) + H(+) + UDP
Comment(s)
  • Adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA, but it adds GlcA when the non-reducing end is GlcNAc.
  • Highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or UDP-GalA.
Cross-references
BRENDA2.4.1.212
EC2PDB2.4.1.212
ExplorEnz2.4.1.212
PRIAM enzyme-specific profiles2.4.1.212
KEGG Ligand Database for Enzyme Nomenclature2.4.1.212
IUBMB Enzyme Nomenclature2.4.1.212
IntEnz2.4.1.212
MEDLINEFind literature relating to 2.4.1.212
MetaCyc2.4.1.212
Rhea expert-curated reactions2.4.1.212
UniProtKB/Swiss-Prot
P0C0H1, HASA_STRP1;  P0DB60, HASA_STRP3;  Q5X9A9, HASA_STRP6;  
Q8NKX1, HASA_STRP8;  P0DB61, HASA_STRPQ;  P0C0H0, HASA_STRPY;  
Q7BLV3, HAS_PASMD;  Q92839, HYAS1_HUMAN;  Q61647, HYAS1_MOUSE;  
P13563, HYAS1_XENLA;  B1WB39, HYAS1_XENTR;  O97711, HYAS2_BOVIN;  
O57424, HYAS2_CHICK;  G5AY81, HYAS2_HETGA;  Q92819, HYAS2_HUMAN;  
P70312, HYAS2_MOUSE;  O35776, HYAS2_RAT;  O57427, HYAS2_XENLA;  
O57425, HYAS3_CHICK;  O00219, HYAS3_HUMAN;  O08650, HYAS3_MOUSE;  
O57426, HYAS3_XENLA;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-