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ENZYME

ENZYME entry: EC 2.4.1.214

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.214
Accepted Name
glycoprotein 3-alpha-L-fucosyltransferase
Alternative Name(s)
GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha1->6-GlcNAc)-Asn- peptide) alpha1->3-fucosyltransferase
GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase
Reaction catalysed
N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP-beta-L-fucose = N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP + H(+)
Comment(s)
  • The enzyme transfers to N-linked oligosaccharide structures (N-glycans), generally with a specificity for N-glycans with one unsubstituted non-reducing terminal GlcNAc residue.
  • This enzyme catalyzes a reaction similar to that of EC 2.4.1.68, but transferring the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,3-linkage rather than an alpha1,6-linkage.
  • The N-glycan products of this enzyme are present in plants, insects and some other invertebrates (e.g., Schistosoma, Haemonchus, Lymnaea).
Cross-references
BRENDA2.4.1.214
EC2PDB2.4.1.214
ExplorEnz2.4.1.214
KEGG Ligand Database for Enzyme Nomenclature2.4.1.214
IUBMB Enzyme Nomenclature2.4.1.214
MEDLINEFind literature relating to 2.4.1.214
MetaCyc2.4.1.214
Rhea expert-curated reactions2.4.1.214
UniProtKB/Swiss-Prot
Q9VUL9, FUCTA_DROMEQ9LJK1, FUT11_ARATHG5EDR5, FUTA_CAEEL

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