ENZYME entry: EC 2.4.1.68
| Accepted Name |
|---|
| Glycoprotein 6-alpha-L-fucosyltransferase.
|
| Alternative Name(s) |
|---|
| GDP-fucose--glycoprotein fucosyltransferase. |
| GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase. |
| GDP-L-fucose-glycoprotein fucosyltransferase. |
| Glycoprotein fucosyltransferase. |
| Guanosine diphosphofucose-glycoprotein fucosyltransferase. |
| Reaction catalysed |
|---|
| GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine <=> GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine |
| Comment(s) |
|---|
| Catalyzes a reaction similar to that of EC 2.4.1.214, but transfers
the L-fucosyl group from GDP-beta-L-fucose to form an alpha-1,6-
linkage rather than an alpha-1,3-linkage.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.68 |
| EC2PDB | 2.4.1.68 |
| ExplorEnz | 2.4.1.68 |
| PRIAM enzyme-specific profiles | 2.4.1.68 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.68 |
| IUBMB Enzyme Nomenclature | 2.4.1.68 |
| IntEnz | 2.4.1.68 |
| MEDLINE | Find literature relating to 2.4.1.68 |
| MetaCyc | 2.4.1.68 |
| UniProtKB/Swiss-Prot |
| Q9N0W2, FUT8_BOVIN; | G5EFE7, FUT8_CAEEL; | Q659X0, FUT8_CANLF; |
| Q9VYV5, FUT8_DROME; | Q9BYC5, FUT8_HUMAN; | Q9WTS2, FUT8_MOUSE; |
| Q6EV77, FUT8_PANTR; | P79282, FUT8_PIG; | Q5NVB3, FUT8_PONAB; |
| Q6EV76, FUT8_RAT; | Q6NVP8, FUT8_XENTR; |
|
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