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ENZYME entry: EC 2.4.1.221

Accepted Name
peptide-O-fucosyltransferase.
Alternative Name(s)
GDP-fucose:polypeptide fucosyltransferase.
GDP-fucose protein O-fucosyltransferase.
GDP-L-fucose:polypeptide fucosyltransferase.
Reaction catalysed
  • GDP-beta-L-fucose + L-seryl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)
  • GDP-beta-L-fucose + L-threonyl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)
Comment(s)
  • The enzyme, found in animals and plants, is involved in the biosynthesis of O-fucosylated proteins.
  • In EGF domains, the attachment of fucose to serine or threonine occurs within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.
Cross-references
BRENDA2.4.1.221
EC2PDB2.4.1.221
ExplorEnz2.4.1.221
PRIAM enzyme-specific profiles2.4.1.221
KEGG Ligand Database for Enzyme Nomenclature2.4.1.221
IUBMB Enzyme Nomenclature2.4.1.221
IntEnz2.4.1.221
MEDLINEFind literature relating to 2.4.1.221
MetaCyc2.4.1.221
Rhea expert-curated reactions2.4.1.221
UniProtKB/Swiss-Prot
Q18014, OFUT1_CAEEL;  P83337, OFUT1_CRIGR;  Q9V6X7, OFUT1_DROME;  
Q9H488, OFUT1_HUMAN;  Q91ZW2, OFUT1_MOUSE;  Q6EV69, OFUT1_PANTR;  
Q6EV70, OFUT1_RAT;  Q8WR51, OFUT2_CAEEL;  Q9W589, OFUT2_DROME;  
Q9Y2G5, OFUT2_HUMAN;  Q8VHI3, OFUT2_MOUSE;  Q6EV56, OFUT2_PANTR;  
A0A509AKB8, OFUT2_PLABA;  W7K6N5, OFUT2_PLAFO;  A5K6G1, OFUT2_PLAVS;  
S7WCF5, OFUT2_TOXGG;  Q96301, SPY_ARATH;  

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