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ENZYME entry: EC 2.4.1.221

Accepted Name
peptide-O-fucosyltransferase
Alternative Name(s)
GDP-fucose protein O-fucosyltransferase
Reaction catalysed
  • GDP-beta-L-fucose + L-seryl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)
  • GDP-beta-L-fucose + L-threonyl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)
Comment(s)
  • The enzyme, found in animals and plants, is involved in the biosynthesis of O-fucosylated proteins.
  • In EGF domains, the attachment of fucose to serine or threonine occurs within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.
Cross-references
BRENDA2.4.1.221
EC2PDB2.4.1.221
ExplorEnz2.4.1.221
PRIAM enzyme-specific profiles2.4.1.221
KEGG Ligand Database for Enzyme Nomenclature2.4.1.221
IUBMB Enzyme Nomenclature2.4.1.221
IntEnz2.4.1.221
MEDLINEFind literature relating to 2.4.1.221
MetaCyc2.4.1.221
Rhea expert-curated reactions2.4.1.221
UniProtKB/Swiss-Prot
Q18014, OFUT1_CAEELP83337, OFUT1_CRIGRQ9V6X7, OFUT1_DROME
Q9H488, OFUT1_HUMANQ91ZW2, OFUT1_MOUSEQ6EV69, OFUT1_PANTR
Q6EV70, OFUT1_RATQ8WR51, OFUT2_CAEELQ9W589, OFUT2_DROME
Q9Y2G5, OFUT2_HUMANQ8VHI3, OFUT2_MOUSEQ6EV56, OFUT2_PANTR
A0A509AKB8, OFUT2_PLABAW7K6N5, OFUT2_PLAFOA5K6G1, OFUT2_PLAVS
S7WCF5, OFUT2_TOXGGQ96301, SPY_ARATH

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