| Accepted Name |
|---|
| O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
|
| Alternative Name(s) |
|---|
| O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase |
| Reaction catalysed |
|---|
- 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)
- 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP + H(+)
|
| Comment(s) |
|---|
- The enzyme, found in animals and plants, is involved in the
biosynthesis of the tetrasaccharide alpha-Neu5A-(2->3)-beta-D-Gal-
(1->4)-beta-D-GlcNAc-(1->3)-L-alpha-Fuc, which is attached to L-Ser
or L-Thr residues within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys
in EGF-like domains.
- The substrate is provided by EC 2.4.1.221.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.222 |
| EC2PDB | 2.4.1.222 |
| ExplorEnz | 2.4.1.222 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.222 |
| IUBMB Enzyme Nomenclature | 2.4.1.222 |
| MEDLINE | Find literature relating to 2.4.1.222 |
| MetaCyc | 2.4.1.222 |
| Rhea expert-curated reactions | 2.4.1.222 |
| UniProtKB/Swiss-Prot |
| Q24342, FNG_DROME | Q2KJ92, LFNG_BOVIN | O12971, LFNG_CHICK |
| Q8JHF2, LFNG_DANRE | Q8NES3, LFNG_HUMAN | O09010, LFNG_MOUSE |
| Q924T4, LFNG_RAT | P79948, LFNG_XENLA | Q5YB40, MFNG_DANRE |
| O00587, MFNG_HUMAN | O09008, MFNG_MOUSE | Q5IS64, MFNG_PANTR |
| O12972, RFNG_CHICK | Q6KFX9, RFNG_DANRE | Q9Y644, RFNG_HUMAN |
| O09009, RFNG_MOUSE | Q9YHB3, RFNG_NOTVI | Q9R1U9, RFNG_RAT |
| P79949, RFNG_XENLA |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-
