ENZYME

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ENZYME entry: EC 2.4.1.223

Accepted Name

Glucuronosyl-galactosyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase.

Alternative Name(s)

Alpha-1,4-N-acetylglucosaminyltransferase.

Alpha-N-acetylglucosaminyltransferase I.

Glucuronosylgalactosyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase.

Glucuronyl-galactosyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase.

Reaction catalysed

UDP-N-acetyl-alpha-D-glucosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine <=> UDP + [protein]-3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Comment(s)

Enzyme involved in the initiation of heparin and heparan sulfate synthesis, transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core.
Apparently products of both the human EXTL2 and EXTL3 genes can catalyze this reaction.
In Caenorhabditis elegans, the product of the rib-2 gene displays this activity as well as that of EC 2.4.1.224.

Cross-references

BRENDA

2.4.1.223

EC2PDB

2.4.1.223

ExplorEnz

2.4.1.223

PRIAM enzyme-specific profiles

2.4.1.223

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.223

IUBMB Enzyme Nomenclature