ENZYME entry: EC 2.4.1.223
Accepted Name |
Glucuronosyl-galactosyl-proteoglycan 4-alpha-N-
acetylglucosaminyltransferase.
|
Alternative Name(s) |
Alpha-1,4-N-acetylglucosaminyltransferase. |
Alpha-N-acetylglucosaminyltransferase I. |
Glucuronosylgalactosyl-proteoglycan 4-alpha-N-
acetylglucosaminyltransferase. |
Glucuronyl-galactosyl-proteoglycan 4-alpha-N-
acetylglucosaminyltransferase. |
Reaction catalysed |
UDP-N-acetyl-alpha-D-glucosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine <=> UDP + [protein]-3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine |
Comment(s) |
- Enzyme involved in the initiation of heparin and heparan sulfate
synthesis, transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core.
- Apparently products of both the human EXTL2 and EXTL3 genes can
catalyze this reaction.
- In Caenorhabditis elegans, the product of the rib-2 gene displays
this activity as well as that of EC 2.4.1.224.
|
Cross-references |
BRENDA | 2.4.1.223 |
EC2PDB | 2.4.1.223 |
ExplorEnz | 2.4.1.223 |
PRIAM enzyme-specific profiles | 2.4.1.223 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.223 |
IUBMB Enzyme Nomenclature | 2.4.1.223 |
IntEnz | 2.4.1.223 |
MEDLINE | Find literature relating to 2.4.1.223 |
MetaCyc | 2.4.1.223 |
UniProtKB/Swiss-Prot |
|
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