Home  |  Contact
Due to work on this service, it may not be fully operational on Wednesday March 20 between 1.30 pm and 2.30 pm CEST. Apologies for the inconvenience.

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase.
Alternative Name(s)
Alpha-N-acetylglucosaminyltransferase II.
Glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N- acetylglucosaminyltransferase.
Reaction catalysed
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan <=> UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan
  • Involved in the biosynthesis of heparin and heparan sulfate.
  • Some forms of the enzyme from human (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the EC activity required for the synthesis of the heparan sulfate disaccharide repeats.
  • Other human forms of this enzyme (e.g. the product of the EXTL1 gene) have only the 4-alpha-N-acetylglucosaminyltransferase activity.
  • In Caenorhabditis elegans, the product of the rib-2 gene displays the activities of this enzyme as well as EC
PRIAM enzyme-specific profiles2.4.1.224
KEGG Ligand Database for Enzyme Nomenclature2.4.1.224
IUBMB Enzyme Nomenclature2.4.1.224
MEDLINEFind literature relating to
Q16394, EXT1_HUMAN;  P97464, EXT1_MOUSE;  A9X1C8, EXT1_PAPAN;  
Q5RBC3, EXT1_PONAB;  O77783, EXT2_BOVIN;  O01705, EXT2_CAEEL;  
Q9Y169, EXT2_DROME;  Q93063, EXT2_HUMAN;  P70428, EXT2_MOUSE;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-