A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.4.1.225
| Accepted Name |
|---|
| N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase.
|
| Alternative Name(s) |
|---|
| Heparan glucuronyltransferase II. |
| N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase. |
| Reaction catalysed |
|---|
| UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan <=> UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan |
| Comment(s) |
|---|
- Involved in the biosynthesis of heparin and heparan sulfate.
- Some forms of the human enzyme (particularly the enzyme complex
encoded by the EXT1 and EXT2 genes) act as bifunctional
glycosyltransferases, which also have the EC 2.4.1.244 activity
required for the synthesis of the heparan sulfate disaccharide
repeats.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.225 |
| EC2PDB | 2.4.1.225 |
| ExplorEnz | 2.4.1.225 |
| PRIAM enzyme-specific profiles | 2.4.1.225 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.225 |
| IUBMB Enzyme Nomenclature | 2.4.1.225 |
| IntEnz | 2.4.1.225 |
| MEDLINE | Find literature relating to 2.4.1.225 |
| MetaCyc | 2.4.1.225 |
| UniProtKB/Swiss-Prot |
| Q5IGR8, EXT1A_DANRE; | Q5IGR7, EXT1B_DANRE; | Q5IGR6, EXT1C_DANRE; |
| A5D7I4, EXT1_BOVIN; | Q9JK82, EXT1_CRIGR; | Q9V730, EXT1_DROME; |
| Q16394, EXT1_HUMAN; | P97464, EXT1_MOUSE; | A9X1C8, EXT1_PAPAN; |
| Q5RBC3, EXT1_PONAB; | O77783, EXT2_BOVIN; | O01705, EXT2_CAEEL; |
| Q9Y169, EXT2_DROME; | Q93063, EXT2_HUMAN; | P70428, EXT2_MOUSE; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-