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ENZYME entry: EC 2.4.1.245

Accepted Name
Alpha,alpha-trehalose synthase.
Alternative Name(s)
Trehalose synthase.
Trehalose synthetase.
Reaction catalysed
NDP-alpha-D-glucose + D-glucose <=> alpha,alpha-trehalose + NDP
Cofactor(s)
Mg(2+).
Comment(s)
  • The enzyme-catalyzed reaction is reversible.
  • In the reverse direction to that shown above, the enzyme is specific for alpha,alpha-trehalose as substrate, as it cannot use alpha- or beta-paranitrophenyl glucosides, maltose, sucrose, lactose or cellobiose.
  • While the enzymes from the thermophilic bacterium Rubrobacter xylanophilus and the hyperthermophilic archaeon Pyrococcus horikoshii can use ADP-, UDP- and GDP-alpha-D-glucose to the same extent, that from the hyperthermophilic archaeon Thermococcus litoralis has a marked preference for ADP-alpha-D-glucose and that from the hyperthermophilic archaeon Thermoproteus tenax has a marked preference for UDP-alpha-D-glucose.
  • Formerly EC 2.4.1.n1.
Cross-references
BRENDA2.4.1.245
EC2PDB2.4.1.245
ExplorEnz2.4.1.245
PRIAM enzyme-specific profiles2.4.1.245
KEGG Ligand Database for Enzyme Nomenclature2.4.1.245
IUBMB Enzyme Nomenclature2.4.1.245
IntEnz2.4.1.245
MEDLINEFind literature relating to 2.4.1.245
MetaCyc2.4.1.245
Rhea expert-curated reactions2.4.1.245
UniProtKB/Swiss-Prot
Q9HH00, TRET_PYRFU;  O58762, TRET_PYRHO;  Q1ARU5, TRET_RUBXD;  
Q7LYW5, TRET_THELN;  

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