ENZYME

ENZYME entry: EC 2.4.1.245

Accepted Name

Alpha,alpha-trehalose synthase.

Alternative Name(s)

Trehalose synthase.

Trehalose synthetase.

Reaction catalysed

NDP-alpha-D-glucose + D-glucose <=> alpha,alpha-trehalose + NDP

Cofactor(s)

Mg(2+).

Comment(s)

The enzyme-catalyzed reaction is reversible.
In the reverse direction to that shown above, the enzyme is specific for alpha,alpha-trehalose as substrate, as it cannot use alpha- or beta-paranitrophenyl glucosides, maltose, sucrose, lactose or cellobiose.
While the enzymes from the thermophilic bacterium Rubrobacter xylanophilus and the hyperthermophilic archaeon Pyrococcus horikoshii can use ADP-, UDP- and GDP-alpha-D-glucose to the same extent, that from the hyperthermophilic archaeon Thermococcus litoralis has a marked preference for ADP-alpha-D-glucose and that from the hyperthermophilic archaeon Thermoproteus tenax has a marked preference for UDP-alpha-D-glucose.
Formerly EC 2.4.1.n1.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature