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ENZYME

ENZYME entry: EC 2.4.1.245

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.245
Accepted Name
alpha,alpha-trehalose synthase
Alternative Name(s)
trehalose synthase
trehalose synthetase
Reaction catalysed
an NDP-alpha-D-glucose + D-glucose = alpha,alpha-trehalose + a ribonucleoside 5'-diphosphate + H(+)
Comment(s)
  • The enzyme-catalyzed reaction is reversible.
  • In the reverse direction to that shown above, the enzyme is specific for alpha,alpha-trehalose as substrate, as it cannot use alpha- or beta-paranitrophenyl glucosides, maltose, sucrose, lactose or cellobiose.
  • While the enzymes from the thermophilic bacterium Rubrobacter xylanophilus and the hyperthermophilic archaeon Pyrococcus horikoshii can use ADP-, UDP- and GDP-alpha-D-glucose to the same extent, that from the hyperthermophilic archaeon Thermococcus litoralis has a marked preference for ADP-alpha-D-glucose and that from the hyperthermophilic archaeon Thermoproteus tenax has a marked preference for UDP-alpha-D-glucose.
  • Formerly EC 2.4.1.n1.
Cross-references
BRENDA2.4.1.245
EC2PDB2.4.1.245
ExplorEnz2.4.1.245
KEGG Ligand Database for Enzyme Nomenclature2.4.1.245
IUBMB Enzyme Nomenclature2.4.1.245
MEDLINEFind literature relating to 2.4.1.245
MetaCyc2.4.1.245
Rhea expert-curated reactions2.4.1.245
UniProtKB/Swiss-Prot
Q9HH00, TRET_PYRFUO58762, TRET_PYRHOQ1ARU5, TRET_RUBXD
Q7LYW5, TRET_THELN

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
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