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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Glucosyl-3-phosphoglycerate synthase.
Alternative Name(s)
Glucosylphosphoglycerate synthase.
GPG synthase.
Reaction catalysed
NDP-glucose + 3-phospho-D-glycerate <=> NDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
  • The enzyme is involved in biosynthesis of 2-O-(alpha-D- glucopyranosyl)-D-glycerate via the two-step pathway in which glucosyl-3-phosphoglycerate synthase catalyzes the conversion of GDP- glucose and 3-phospho-D-glycerate into 2-O-(alpha-D-glucopyranosyl)- 3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D- glucopyranosyl)-D-glycerate by EC
  • The activity is dependent on divalent cations (Mn(2+), Co(2+), or Mg(2+)).
  • The enzyme from Persephonella marina shows moderate flexibility on the sugar donor concerning the nucleotide moiety (UDP-glucose, ADP- glucose, GDP-glucose) but is strictly specific for glucose.
  • The enzyme is also strictly specific for 3-phospho-D-glycerate as acceptor.
  • The enzyme from Methanococcoides burtonii is strictly specific for GDP-glucose and 3-phospho-D-glycerate.
  • This enzyme catalyzes the first glucosylation step in methylglucose lipopolysaccharide biosynthesis in mycobacteria.
PRIAM enzyme-specific profiles2.4.1.266
KEGG Ligand Database for Enzyme Nomenclature2.4.1.266
IUBMB Enzyme Nomenclature2.4.1.266
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