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ENZYME entry: EC 2.4.1.344

Accepted Name
Type 2 galactoside alpha-(1,2)-fucosyltransferase.
Alternative Name(s)
Alpha-(1->2)-L-fucosyltransferase.
Alpha-2-fucosyltransferase.
Alpha-2-L-fucosyltransferase.
Beta-galactoside-alpha(1->2)fucosyltransferase.
Blood group H alpha-2-fucosyltransferase.
Blood-group substance H-dependent fucosyltransferase.
GDP fucose-lactose fucosyltransferase.
Guanosine diphospho-L-fucose-lactose fucosyltransferase.
Guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase.
Guanosine diphosphofucose-galactoside 2-L-fucosyltransferase.
Guanosine diphosphofucose- galactosylacetylglucosaminylgalactosylglucosylceramide-alpha-L- fucosyltransferase.
Guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase.
Guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase.
Guanosine diphosphofucose-lactose fucosyltransferase.
H-gene-encoded beta-galactoside-alpha(1->2)fucosyltransferase.
Reaction catalysed
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R <=> GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R
Comment(s)
  • The enzyme acts on a glycoconjugates where the substituent is a glycoprotein or glycosphingolipid.
  • The recognized moiety of the substrate is known as a type 2 histo- blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 2 antigen.
  • Cf. EC 2.4.1.69.
Cross-references
BRENDA2.4.1.344
EC2PDB2.4.1.344
ExplorEnz2.4.1.344
PRIAM enzyme-specific profiles2.4.1.344
KEGG Ligand Database for Enzyme Nomenclature2.4.1.344
IUBMB Enzyme Nomenclature2.4.1.344
IntEnz2.4.1.344
MEDLINEFind literature relating to 2.4.1.344
MetaCyc2.4.1.344
UniProtKB/Swiss-Prot
Q866E1, FUT1_ALOBE;  Q866E4, FUT1_ALOCA;  Q866E6, FUT1_AOTAZ;  
Q866E7, FUT1_AOTNA;  Q866C7, FUT1_ATEBE;  F6Q1T7, FUT1_BOVIN;  
Q9TUD4, FUT1_GORGO;  P19526, FUT1_HUMAN;  Q866C9, FUT1_LAGLA;  
Q866D6, FUT1_LEOCY;  Q866D2, FUT1_LEOFU;  Q866D9, FUT1_MICHU;  
O09160, FUT1_MOUSE;  Q9TUD6, FUT1_PANTR;  Q29043, FUT1_PIG;  
Q866C5, FUT1_PLEBR;  Q10979, FUT1_RABIT;  Q10980, FUT1_RAT;  
Q866F0, FUT1_SAIBB;  Q866F1, FUT1_SAISC;  Q866E8, FUT1_SAPAP;  
Q28113, FUT2_BOVIN;  O77486, FUT2_GORGO;  Q10981, FUT2_HUMAN;  
Q9TTC7, FUT2_HYLLA;  Q9JL27, FUT2_MOUSE;  O77485, FUT2_PANTR;  
Q10982, FUT2_PIG;  O77487, FUT2_PONPY;  Q10983, FUT2_RABIT;  
Q10984, FUT2_RAT;  

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