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ENZYME

ENZYME entry: EC 2.4.1.69

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.69
Accepted Name
type 1 galactoside alpha-(1,2)-fucosyltransferase
Alternative Name(s)
alpha-(1->2)-L-fucosyltransferase
alpha-2-fucosyltransferase
alpha-2-L-fucosyltransferase
beta-galactoside alpha1->2 fucosyltransferase
blood group H alpha-2-fucosyltransferase
blood-group substance H-dependent fucosyltransferase
galactoside 2-alpha-L-fucosyltransferase
guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase
guanosine diphosphofucose-galactoside 2-L-fucosyltransferase
guanosine diphosphofucose- galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L- fucosyltransferase
guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase
guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase
secretor-type beta-galactoside alpha1->2 fucosyltransferase
Reaction catalysed
a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)
Comment(s)
  • The enzyme acts on a glycoconjugates where the substituent group is a glycoprotein or glycosphingolipid.
  • The recognized moiety of the substrate is known as a type 1 histo- blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen.
  • The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates (see EC 2.4.1.344).
  • Formerly EC 2.4.1.89.
Cross-references
BRENDA2.4.1.69
EC2PDB2.4.1.69
ExplorEnz2.4.1.69
KEGG Ligand Database for Enzyme Nomenclature2.4.1.69
IUBMB Enzyme Nomenclature2.4.1.69
MEDLINEFind literature relating to 2.4.1.69
MetaCyc2.4.1.69
Rhea expert-curated reactions2.4.1.69
UniProtKB/Swiss-Prot
Q866E1, FUT1_ALOBEQ866E4, FUT1_ALOCAQ866E6, FUT1_AOTAZ
Q866E7, FUT1_AOTNAQ866C7, FUT1_ATEBEF6Q1T7, FUT1_BOVIN
Q9TUD4, FUT1_GORGOP19526, FUT1_HUMANQ866C9, FUT1_LAGLA
Q866D6, FUT1_LEOCYQ866D2, FUT1_LEOFUQ866D9, FUT1_MICHU
O09160, FUT1_MOUSEQ9TUD6, FUT1_PANTRQ29043, FUT1_PIG
Q866C5, FUT1_PLEBRQ10979, FUT1_RABITQ10980, FUT1_RAT
Q866F0, FUT1_SAIBBQ866F1, FUT1_SAISCQ866E8, FUT1_SAPAP
Q28113, FUT2_BOVINO77486, FUT2_GORGOQ10981, FUT2_HUMAN
Q9TTC7, FUT2_HYLLAQ9JL27, FUT2_MOUSEO77485, FUT2_PANTR
Q10982, FUT2_PIGO77487, FUT2_PONPYQ10983, FUT2_RABIT
Q10984, FUT2_RATQ54QG0, PGFB_DICDI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-