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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.1.69

Accepted Name
Type 1 galactoside alpha-(1,2)-fucosyltransferase.
Alternative Name(s)
Alpha-(1->2)-L-fucosyltransferase.
Alpha-2-fucosyltransferase.
Alpha-2-L-fucosyltransferase.
Beta-galactoside alpha-1->2 fucosyltransferase.
Blood group H alpha-2-fucosyltransferase.
Blood-group substance H-dependent fucosyltransferase.
Galactoside 2-alpha-L-fucosyltransferase.
Guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase.
Guanosine diphosphofucose-galactoside 2-L-fucosyltransferase.
Guanosine diphosphofucose- galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L- fucosyltransferase.
Guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase.
Guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase.
Secretor-type beta-galactoside alpha-1->2 fucosyltransferase.
Reaction catalysed
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R <=> GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Comment(s)
  • The enzyme acts on a glycoconjugates where the substituent group is a glycoprotein or glycosphingolipid.
  • The recognized moiety of the substrate is known as a type 1 histo- blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen.
  • The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates (see EC 2.4.1.344).
  • Formerly EC 2.4.1.89.
Cross-references
BRENDA2.4.1.69
EC2PDB2.4.1.69
ExplorEnz2.4.1.69
PRIAM enzyme-specific profiles2.4.1.69
KEGG Ligand Database for Enzyme Nomenclature2.4.1.69
IUBMB Enzyme Nomenclature2.4.1.69
IntEnz2.4.1.69
MEDLINEFind literature relating to 2.4.1.69
MetaCyc2.4.1.69
UniProtKB/Swiss-Prot
Q28113, FUT2_BOVIN;  O77486, FUT2_GORGO;  Q10981, FUT2_HUMAN;  
Q9TTC7, FUT2_HYLLA;  Q9JL27, FUT2_MOUSE;  O77485, FUT2_PANTR;  
Q10982, FUT2_PIG;  O77487, FUT2_PONPY;  Q10983, FUT2_RABIT;  
Q10984, FUT2_RAT;  Q54QG0, PGFB_DICDI;  P97353, SEC1_MOUSE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-