ENZYME entry: EC 2.4.1.69

Accepted Name

type 1 galactoside alpha-(1,2)-fucosyltransferase

Alternative Name(s)

alpha-(1->2)-L-fucosyltransferase

alpha-2-fucosyltransferase

alpha-2-L-fucosyltransferase

beta-galactoside alpha1->2 fucosyltransferase

blood group H alpha-2-fucosyltransferase

blood-group substance H-dependent fucosyltransferase

galactoside 2-alpha-L-fucosyltransferase

guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase

guanosine diphosphofucose-galactoside 2-L-fucosyltransferase

guanosine diphosphofucose- galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L- fucosyltransferase

guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase

guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase

secretor-type beta-galactoside alpha1->2 fucosyltransferase

Reaction catalysed

a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)

Comment(s)

The enzyme acts on a glycoconjugates where the substituent group is a glycoprotein or glycosphingolipid.
The recognized moiety of the substrate is known as a type 1 histo- blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen.
The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates (see EC 2.4.1.344).
Formerly EC 2.4.1.89.

Cross-references

BRENDA

2.4.1.69

EC2PDB

2.4.1.69

ExplorEnz

2.4.1.69

PRIAM enzyme-specific profiles

2.4.1.69

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.69

IUBMB Enzyme Nomenclature

2.4.1.69

IntEnz

2.4.1.69

MEDLINE

Find literature relating to 2.4.1.69

MetaCyc

2.4.1.69

Rhea expert-curated reactions

2.4.1.69

UniProtKB/Swiss-Prot

Q866E1, FUT1_ALOBE	Q866E4, FUT1_ALOCA	Q866E6, FUT1_AOTAZ
Q866E7, FUT1_AOTNA	Q866C7, FUT1_ATEBE	F6Q1T7, FUT1_BOVIN
Q9TUD4, FUT1_GORGO	P19526, FUT1_HUMAN	Q866C9, FUT1_LAGLA
Q866D6, FUT1_LEOCY	Q866D2, FUT1_LEOFU	Q866D9, FUT1_MICHU
O09160, FUT1_MOUSE	Q9TUD6, FUT1_PANTR	Q29043, FUT1_PIG
Q866C5, FUT1_PLEBR	Q10979, FUT1_RABIT	Q10980, FUT1_RAT
Q866F0, FUT1_SAIBB	Q866F1, FUT1_SAISC	Q866E8, FUT1_SAPAP
Q28113, FUT2_BOVIN	O77486, FUT2_GORGO	Q10981, FUT2_HUMAN
Q9TTC7, FUT2_HYLLA	Q9JL27, FUT2_MOUSE	O77485, FUT2_PANTR
Q10982, FUT2_PIG	O77487, FUT2_PONPY	Q10983, FUT2_RABIT
Q10984, FUT2_RAT	Q54QG0, PGFB_DICDI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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