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ENZYME entry: EC 2.4.1.69

Accepted Name
type 1 galactoside alpha-(1,2)-fucosyltransferase.
Alternative Name(s)
alpha-(1->2)-L-fucosyltransferase.
alpha-2-fucosyltransferase.
alpha-2-L-fucosyltransferase.
beta-galactoside alpha1->2 fucosyltransferase.
blood group H alpha-2-fucosyltransferase.
blood-group substance H-dependent fucosyltransferase.
galactoside 2-alpha-L-fucosyltransferase.
guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase.
guanosine diphosphofucose-galactoside 2-L-fucosyltransferase.
guanosine diphosphofucose- galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L- fucosyltransferase.
guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase.
guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase.
secretor-type beta-galactoside alpha1->2 fucosyltransferase.
Reaction catalysed
a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)
Comment(s)
  • The enzyme acts on a glycoconjugates where the substituent group is a glycoprotein or glycosphingolipid.
  • The recognized moiety of the substrate is known as a type 1 histo- blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen.
  • The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates (see EC 2.4.1.344).
  • Formerly EC 2.4.1.89.
Cross-references
BRENDA2.4.1.69
EC2PDB2.4.1.69
ExplorEnz2.4.1.69
PRIAM enzyme-specific profiles2.4.1.69
KEGG Ligand Database for Enzyme Nomenclature2.4.1.69
IUBMB Enzyme Nomenclature2.4.1.69
IntEnz2.4.1.69
MEDLINEFind literature relating to 2.4.1.69
MetaCyc2.4.1.69
Rhea expert-curated reactions2.4.1.69
UniProtKB/Swiss-Prot
Q866E1, FUT1_ALOBE;  Q866E4, FUT1_ALOCA;  Q866E6, FUT1_AOTAZ;  
Q866E7, FUT1_AOTNA;  Q866C7, FUT1_ATEBE;  F6Q1T7, FUT1_BOVIN;  
Q9TUD4, FUT1_GORGO;  P19526, FUT1_HUMAN;  Q866C9, FUT1_LAGLA;  
Q866D6, FUT1_LEOCY;  Q866D2, FUT1_LEOFU;  Q866D9, FUT1_MICHU;  
O09160, FUT1_MOUSE;  Q9TUD6, FUT1_PANTR;  Q29043, FUT1_PIG;  
Q866C5, FUT1_PLEBR;  Q10979, FUT1_RABIT;  Q10980, FUT1_RAT;  
Q866F0, FUT1_SAIBB;  Q866F1, FUT1_SAISC;  Q866E8, FUT1_SAPAP;  
Q28113, FUT2_BOVIN;  O77486, FUT2_GORGO;  Q10981, FUT2_HUMAN;  
Q9TTC7, FUT2_HYLLA;  Q9JL27, FUT2_MOUSE;  O77485, FUT2_PANTR;  
Q10982, FUT2_PIG;  O77487, FUT2_PONPY;  Q10983, FUT2_RABIT;  
Q10984, FUT2_RAT;  Q54QG0, PGFB_DICDI;  

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