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ENZYME entry: EC 2.4.1.360

Accepted Name
2-hydroxyflavanone C-glucosyltransferase.
Reaction catalysed
UDP-alpha-D-glucose + a 2'-hydroxy-beta-oxodihydrochalcone <=> UDP + a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone
Comment(s)
  • The enzyme has been characterized in Oryza sativa (rice), various Citrus spp., Glycine max (soybean), and Fagopyrum esculentum (buckwheat).
  • Flavanone substrates require a 2-hydroxy group.
  • The meta-stable flavanone substrates such as 2-hydroxynaringenin exist in an equilibrium with open forms such as 1-(4-hydroxyphenyl)- 3-(2,4,6-trihydroxyphenyl)propane-1,3-dione, which are the actual substrates for the glucosyl-transfer reaction (see EC 1.14.14.162).
  • The enzyme can also act on dihydrochalcones.
  • The enzymes from citrus plants can catalyze a second C-glycosylation reaction at position 5.
Cross-references
BRENDA2.4.1.360
EC2PDB2.4.1.360
ExplorEnz2.4.1.360
PRIAM enzyme-specific profiles2.4.1.360
KEGG Ligand Database for Enzyme Nomenclature2.4.1.360
IUBMB Enzyme Nomenclature2.4.1.360
IntEnz2.4.1.360
MEDLINEFind literature relating to 2.4.1.360
MetaCyc2.4.1.360
Rhea expert-curated reactions2.4.1.360
UniProtKB/Swiss-Prot
A0A0A1HA03, 708C1_FAGES;  A0A0A1H7N4, 708C2_FAGES;  I1L3T1, 708D1_SOYBN;  
A0A224AM54, 708G1_CITJP;  A0A224AKZ9, 708G2_CITUN;  C3W7B0, CGT_ORYSI;  
Q5VMI0, CGT_ORYSJ;  

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