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ENZYME

ENZYME entry: EC 2.4.1.79

Accepted Name
globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase
Alternative Name(s)
beta3GalNAc-T1
galactosylgalactosylglucosylceramide beta-D- acetylgalactosaminyltransferase
globoside synthase
globoside synthetase
uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase
Reaction catalysed
globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Gb4Cer (d18:1(4E)) + H(+) + UDP
Comment(s)
  • Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity.
  • UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity.
  • Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates.
Cross-references
BRENDA2.4.1.79
EC2PDB2.4.1.79
ExplorEnz2.4.1.79
PRIAM enzyme-specific profiles2.4.1.79
KEGG Ligand Database for Enzyme Nomenclature2.4.1.79
IUBMB Enzyme Nomenclature2.4.1.79
IntEnz2.4.1.79
MEDLINEFind literature relating to 2.4.1.79
MetaCyc2.4.1.79
Rhea expert-curated reactions2.4.1.79
UniProtKB/Swiss-Prot
O75752, B3GL1_HUMANQ920V1, B3GL1_MOUSEQ793U7, B3GL1_MUSSI
Q864U6, B3GL1_PIGQ5RAL7, B3GL1_PONABQ6AY39, B3GL1_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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