ENZYME entry: EC 2.4.1.79
Accepted Name |
Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase.
|
Alternative Name(s) |
Beta-3GalNAc-T1. |
Galactosylgalactosylglucosylceramide beta-D-
acetylgalactosaminyltransferase. |
Globoside synthase. |
Globoside synthetase. |
Uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide
acetylgalactosaminyltransferase. |
Reaction catalysed |
UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide <=> UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide |
Cofactor(s) |
Mn(2+).
|
Comment(s) |
- Globoside is a neutral glycosphingolipid in human erythrocytes and
has blood-group-P-antigen activity.
- UDP-GalNAc is the only sugar donor that is used efficiently by the
enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity.
- Lactosylceramide, globoside and gangliosides GM3 and GD3 are not
substrates.
|
Cross-references |
BRENDA | 2.4.1.79 |
EC2PDB | 2.4.1.79 |
ExplorEnz | 2.4.1.79 |
PRIAM enzyme-specific profiles | 2.4.1.79 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.79 |
IUBMB Enzyme Nomenclature | 2.4.1.79 |
IntEnz | 2.4.1.79 |
MEDLINE | Find literature relating to 2.4.1.79 |
MetaCyc | 2.4.1.79 |
Rhea expert-curated reactions | 2.4.1.79 |
UniProtKB/Swiss-Prot |
|
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