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ENZYME entry: EC 2.4.1.79

Accepted Name
Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase.
Alternative Name(s)
Beta-3GalNAc-T1.
Galactosylgalactosylglucosylceramide beta-D- acetylgalactosaminyltransferase.
Globoside synthase.
Globoside synthetase.
Uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase.
Reaction catalysed
UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide <=> UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Cofactor(s)
Mn(2+).
Comment(s)
  • Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity.
  • UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity.
  • Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates.
Cross-references
BRENDA2.4.1.79
EC2PDB2.4.1.79
ExplorEnz2.4.1.79
PRIAM enzyme-specific profiles2.4.1.79
KEGG Ligand Database for Enzyme Nomenclature2.4.1.79
IUBMB Enzyme Nomenclature2.4.1.79
IntEnz2.4.1.79
MEDLINEFind literature relating to 2.4.1.79
MetaCyc2.4.1.79
Rhea expert-curated reactions2.4.1.79
UniProtKB/Swiss-Prot
O75752, B3GL1_HUMAN;  Q920V1, B3GL1_MOUSE;  Q793U7, B3GL1_MUSSI;  
Q864U6, B3GL1_PIG;  Q5RAL7, B3GL1_PONAB;  Q6AY39, B3GL1_RAT;  

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