ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.1.79

Accepted Name

Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase.

Alternative Name(s)

Beta-3GalNAc-T1.

Galactosylgalactosylglucosylceramide beta-D- acetylgalactosaminyltransferase.

Globoside synthase.

Globoside synthetase.

Uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase.

Reaction catalysed

UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide <=> UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Cofactor(s)

Mn(2+).

Comment(s)

Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity.
UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity.
Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates.

Cross-references

BRENDA

2.4.1.79

EC2PDB

2.4.1.79

ExplorEnz

2.4.1.79

PRIAM enzyme-specific profiles

2.4.1.79

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.79

IUBMB Enzyme Nomenclature