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ENZYME

ENZYME entry: EC 2.4.2.29

Accepted Name
tRNA-guanosine(34) preQ1 transglycosylase
Alternative Name(s)
guanine insertion enzyme
Q-insertase
TGT
tRNA guanine(34) transglycosidase
tRNA transglycosylase
Reaction catalysed
7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA <=> 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine
Comment(s)
  • Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34.
  • In eubacteria, which produce queuine de novo, the enzyme catalyzes the exchange of guanine with the queuine precursor preQ1, which is ultimately modified to queuosine.
  • The enzyme can also use an earlier intermediate, preQ0, to replace guanine in unmodified tRNA(Tyr) and tRNA(Asn).
  • This enzyme acts after EC 1.7.1.13 in the queuine-biosynthesis pathway. cf. EC 2.4.2.64.
Cross-references
BRENDA2.4.2.29
EC2PDB2.4.2.29
ExplorEnz2.4.2.29
PRIAM enzyme-specific profiles2.4.2.29
KEGG Ligand Database for Enzyme Nomenclature2.4.2.29
IUBMB Enzyme Nomenclature2.4.2.29
IntEnz2.4.2.29
MEDLINEFind literature relating to 2.4.2.29
MetaCyc2.4.2.29
Rhea expert-curated reactions2.4.2.29
UniProtKB/Swiss-Prot
A3DE13, TGT_ACET2Q6FEJ4, TGT_ACIADB7GWL4, TGT_ACIB3
B7I976, TGT_ACIB5B2HYN7, TGT_ACIBCB0VRA8, TGT_ACIBS
A3M8S3, TGT_ACIBTB0V625, TGT_ACIBYB9MGI1, TGT_ACIET
B7J4R9, TGT_ACIF2B5EK08, TGT_ACIF5A1WCK2, TGT_ACISJ
A3N087, TGT_ACTP2B3GXF8, TGT_ACTP7B0BP03, TGT_ACTPJ
A6VN75, TGT_ACTSZA0KJ20, TGT_AERHHA4SP26, TGT_AERS4
Q8UES8, TGT_AGRFCA8ERD1, TGT_ALIB4Q5E3D2, TGT_ALIF1
B5F9Y3, TGT_ALIFMB6EK65, TGT_ALISLQ5WHR2, TGT_ALKCK
B7GFN1, TGT_ANOFWO67331, TGT_AQUAEO28787, TGT_ARCFU
Q5P720, TGT_AROAEA1K3W9, TGT_AZOSBC1DE76, TGT_AZOVD
C3P9A4, TGT_BACAAC3L6U6, TGT_BACACA0RJ24, TGT_BACAH
Q81LH2, TGT_BACANB7JQ03, TGT_BACC0Q730B4, TGT_BACC1
B7IIS9, TGT_BACC2C1ESW1, TGT_BACC3B7HE51, TGT_BACC4
B7HQH6, TGT_BACC7A7GT99, TGT_BACCNB9IYZ1, TGT_BACCQ
Q817W6, TGT_BACCRQ634C7, TGT_BACCZQ6HDA9, TGT_BACHK
Q65GP9, TGT_BACLDA9VIP3, TGT_BACMKA8FFQ9, TGT_BACP2
O32053, TGT_BACSUA7Z766, TGT_BACVZQ1LSP0, TGT_BAUCH
Q7VQB1, TGT_BLOFLQ493H3, TGT_BLOPBO51749, TGT_BORBU
B7J0Q4, TGT_BORBZB5RN03, TGT_BORDLQ65ZW4, TGT_BORGP
B2S1F3, TGT_BORHDB5RQE7, TGT_BORRAA1R0N4, TGT_BORT9
C0R0X6, TGT_BRAHWQ8YHB2, TGT_BRUMEQ8G0K1, TGT_BRUSU
B8D8T4, TGT_BUCA5P57233, TGT_BUCAIQ8KA09, TGT_BUCAP
B8D738, TGT_BUCATQ8RAM9, TGT_CALS4A7ZD89, TGT_CAMC1
A7GYD5, TGT_CAMC5A0RPL5, TGT_CAMFFA7I2I6, TGT_CAMHC
A8FM59, TGT_CAMJ8A7H331, TGT_CAMJDQ9PNT0, TGT_CAMJE
A1VZZ8, TGT_CAMJJQ5HUF2, TGT_CAMJRB9KFT3, TGT_CAMLR
Q9A7Y1, TGT_CAUVCA3PJT9, TGT_CERS1Q3J2H4, TGT_CERS4
Q5L5T1, TGT_CHLABQ822U8, TGT_CHLCVQ254U7, TGT_CHLFF
Q9PKK0, TGT_CHLMUQ9Z8W5, TGT_CHLPNB0B9U3, TGT_CHLT2
Q3KMG9, TGT_CHLTAB0BBH3, TGT_CHLTBO84196, TGT_CHLTR
Q1QTM9, TGT_CHRSDQ7NYC7, TGT_CHRVOA8AK48, TGT_CITK8
Q97GT3, TGT_CLOABA7FY17, TGT_CLOB1C3KTD0, TGT_CLOB6
A5I6E9, TGT_CLOBHC1FKF9, TGT_CLOBJB1IMF1, TGT_CLOBK
A7GHT6, TGT_CLOBLB1L0B0, TGT_CLOBMB9E5Q6, TGT_CLOK1
A5N204, TGT_CLOK5Q0TP15, TGT_CLOP1Q8XJ16, TGT_CLOPE
Q0SRN5, TGT_CLOPSQ892A0, TGT_CLOTEQ1LJ59, TGT_CUPMC
Q0K733, TGT_CUPNHQ46XG4, TGT_CUPPJB3R6J4, TGT_CUPTR
B8HX02, TGT_CYAP4Q47AX3, TGT_DECARQ3ZAE2, TGT_DEHM1
A5FSU3, TGT_DEHMBQ3ZWC1, TGT_DEHMCQ9RRB5, TGT_DEIRA
A9BRD7, TGT_DELASC0QKY2, TGT_DESAHB1I4K8, TGT_DESAP
B8FQV2, TGT_DESHDA8ZRX7, TGT_DESOHA4J541, TGT_DESRM
Q72E53, TGT_DESVHA1VFP3, TGT_DESVVA5EW66, TGT_DICNV
B5YFK5, TGT_DICT6B8E2N5, TGT_DICTDA8LRQ1, TGT_DINSH
A7ZIF8, TGT_ECO24B7UJM9, TGT_ECO27B7MD64, TGT_ECO45
B7L639, TGT_ECO55P0A849, TGT_ECO57B5Z2W2, TGT_ECO5E
B7NJ96, TGT_ECO7IB7MPG7, TGT_ECO81B7M3P5, TGT_ECO8A
C4ZTG3, TGT_ECOBWB1XEZ4, TGT_ECODHA7ZX57, TGT_ECOHS
A1A876, TGT_ECOK1Q0TKN5, TGT_ECOL5P0A848, TGT_ECOL6
B1J043, TGT_ECOLCP0A847, TGT_ECOLIB7N8V8, TGT_ECOLU
B6HZK6, TGT_ECOSEB1LJF4, TGT_ECOSMQ1RFD5, TGT_ECOUT
C5BCF7, TGT_EDWI9A4W779, TGT_ENT38Q837E7, TGT_ENTFA
B2VHQ1, TGT_ERWT9B7LMI1, TGT_ESCF3B0TYY3, TGT_FRAP2
Q14HA0, TGT_FRAT1A7NBL6, TGT_FRATFQ2A3Y7, TGT_FRATH
B2SHD4, TGT_FRATMA0Q6X1, TGT_FRATNQ0BMC7, TGT_FRATO
Q5NFU8, TGT_FRATTA4IYF8, TGT_FRATWQ8RDN0, TGT_FUSNN
Q5KWR4, TGT_GEOKAA4IRA9, TGT_GEOTNB8F3W0, TGT_GLAP5
Q7NMG4, TGT_GLOVIA9HBJ2, TGT_GLUDAQ0BVG4, TGT_GRABC
Q7VLQ4, TGT_HAEDUQ4QNU3, TGT_HAEI8A5UAP3, TGT_HAEIE
A5UG47, TGT_HAEIGP44594, TGT_HAEINQ9KDI5, TGT_HALH5
B8CXG0, TGT_HALOHC4K8M3, TGT_HAMD5Q17YB5, TGT_HELAH
Q7VHX2, TGT_HELHPB6JKL0, TGT_HELP2B5ZA47, TGT_HELPG
Q1CUM2, TGT_HELPHQ9ZMF4, TGT_HELPJB2USB2, TGT_HELPS
O08314, TGT_HELPYA9AW42, TGT_HERA2A4G1Z3, TGT_HERAR
Q0I4R8, TGT_HISS1Q31FZ5, TGT_HYDCUQ5QVL2, TGT_IDILO
A6SUU4, TGT_JANMAQ28PC5, TGT_JANSCB5Y0Y6, TGT_KLEP3
A6T5D8, TGT_KLEP7Q1IVF1, TGT_KORVEC4Z563, TGT_LACE2
Q9CJ54, TGT_LACLAA2RHN5, TGT_LACLMQ032U4, TGT_LACLS
A9KHU4, TGT_LACP7Q88V05, TGT_LACPLC1DDA7, TGT_LARHH
Q38YP9, TGT_LATSSQ1MPU5, TGT_LAWIPB0SCA8, TGT_LEPBA
Q04UC6, TGT_LEPBJQ04Z48, TGT_LEPBLB0SKS9, TGT_LEPBP
B1XWG6, TGT_LEPCPQ72TL3, TGT_LEPICQ8CXS3, TGT_LEPIN
Q92BI4, TGT_LISINC1KVH7, TGT_LISMCQ71ZE0, TGT_LISMF
B8DHL8, TGT_LISMHQ8Y700, TGT_LISMOA0AIX9, TGT_LISW6
B1HVA1, TGT_LYSSCB9E716, TGT_MACCJQ65S94, TGT_MANSM
A1TZN7, TGT_MARN8Q1H403, TGT_METFKB3DYE4, TGT_METI4
A2SM97, TGT_METPPQ2RHU3, TGT_MOOTAB2A5K8, TGT_NATTJ
B9L8E1, TGT_NAUPAQ5F9U5, TGT_NEIG1B4RJY2, TGT_NEIG2
A9M374, TGT_NEIM0Q9JVA4, TGT_NEIMAQ9K096, TGT_NEIMB
A1KSY1, TGT_NEIMFQ0AG55, TGT_NITECQ82VF0, TGT_NITEU
Q2Y6A3, TGT_NITMUA6Q3Y5, TGT_NITSBQ8YVT9, TGT_NOSS1
Q2G639, TGT_NOVADQ8CXC4, TGT_OCEIHQ30XF7, TGT_OLEA2
A1TVN0, TGT_PARC0Q7TTX7, TGT_PARMWQ6MD31, TGT_PARUW
P57831, TGT_PASMUQ6D855, TGT_PECASC6DB26, TGT_PECCP
Q03ER2, TGT_PEDPAA5D3G6, TGT_PELTSQ7MB01, TGT_PHOLL
Q6LU69, TGT_PHOPRA1VJ15, TGT_POLNAQ12GB2, TGT_POLSJ
A3PAZ2, TGT_PROM0A8G2T1, TGT_PROM2A2CCL1, TGT_PROM3
A9BDP3, TGT_PROM4A2BUQ2, TGT_PROM5Q31CR1, TGT_PROM9
Q7VDR5, TGT_PROMAB4EU13, TGT_PROMHQ7TUM6, TGT_PROMM
Q7TUG0, TGT_PROMPA2BP70, TGT_PROMSQ15WI4, TGT_PSEA6
B7UVU4, TGT_PSEA8Q02RX7, TGT_PSEABQ9HXH9, TGT_PSEAE
Q88PL7, TGT_PSEPKQ887B0, TGT_PSESMQ3ILB8, TGT_PSET1
Q4FRI6, TGT_PSYA2Q1QA23, TGT_PSYCKA1SWU0, TGT_PSYIN
A5WGS6, TGT_PSYWFQ8XVW4, TGT_RALN1B2UC75, TGT_RALPJ
Q98M57, TGT_RHILOQ92PY4, TGT_RHIMEQ7UWK9, TGT_RHOBA
C3PLJ4, TGT_RICAEA8GPN2, TGT_RICAHA8GUA5, TGT_RICB8
Q1RH25, TGT_RICBRA8EZT7, TGT_RICCKQ92GM6, TGT_RICCN
Q4UN16, TGT_RICFEA8F2K6, TGT_RICM5Q9ZCK8, TGT_RICPR
C4K0T2, TGT_RICPUB0BUZ2, TGT_RICROA8GTF4, TGT_RICRS
Q68W26, TGT_RICTYA5USV3, TGT_ROSS1Q5LQ80, TGT_RUEPO
Q1GIL3, TGT_RUESTB8I6M0, TGT_RUMCHQ21KW1, TGT_SACD2
B5EWT9, TGT_SALA4A9MM57, TGT_SALARQ57SF8, TGT_SALCH
B5FKR0, TGT_SALDCB5QTF4, TGT_SALEPB5R6Q7, TGT_SALG2
B4T8P5, TGT_SALHSB4SWP7, TGT_SALNSQ5PFT6, TGT_SALPA
A9MX29, TGT_SALPBC0Q7S9, TGT_SALPCB5BDC8, TGT_SALPK
B4TZI0, TGT_SALSVQ8Z8Y0, TGT_SALTIQ8ZRD8, TGT_SALTY
A8GAM5, TGT_SERP5A1S7P2, TGT_SHEAMB8EDJ7, TGT_SHEB2
A3D6B1, TGT_SHEB5A6WQ52, TGT_SHEB8A9KUN0, TGT_SHEB9
Q12PD9, TGT_SHEDOQ07ZM2, TGT_SHEFNB0TND4, TGT_SHEHH
A3QFF5, TGT_SHELPQ8ECM3, TGT_SHEONA8H2K8, TGT_SHEPA
A4Y8C2, TGT_SHEPCB8CLC5, TGT_SHEPWA0KV50, TGT_SHESA
A8FXC6, TGT_SHESHQ0HKF7, TGT_SHESMQ0HWQ9, TGT_SHESR
A1RI67, TGT_SHESWB2U4K7, TGT_SHIB3Q325J5, TGT_SHIBS
Q32JG0, TGT_SHIDSQ0T7I3, TGT_SHIF8Q54177, TGT_SHIFL
Q3Z503, TGT_SHISSQ2NVA4, TGT_SODGMC4XSI9, TGT_SOLM1
Q029K6, TGT_SOLUEA9FI06, TGT_SORC5Q1GR26, TGT_SPHAL
A7X354, TGT_STAA1A6U2A7, TGT_STAA2Q2FG88, TGT_STAA3
Q2FXT6, TGT_STAA8A5ITG3, TGT_STAA9Q2YT91, TGT_STAAB
Q5HFC4, TGT_STAACA6QHI1, TGT_STAAEP66904, TGT_STAAM
P66905, TGT_STAANQ6GG65, TGT_STAARQ6G8T0, TGT_STAAS
A8Z2G7, TGT_STAATP66906, TGT_STAAWB9DNG7, TGT_STACT
Q5HNR2, TGT_STAEQQ8CML7, TGT_STAESQ4L6Y4, TGT_STAHJ
Q3K2Y7, TGT_STRA1Q8E6X6, TGT_STRA3Q8E1F9, TGT_STRA5
C0MAH5, TGT_STRE4A8AUL3, TGT_STRGCB4SSS1, TGT_STRM5
B2FN00, TGT_STRMKQ8DVZ3, TGT_STRMUQ9A1L6, TGT_STRP1
Q04IB3, TGT_STRP2P0DF86, TGT_STRP3B5E2X9, TGT_STRP4
Q5XE18, TGT_STRP6C1CAA6, TGT_STRP7P66910, TGT_STRP8
Q1JDS0, TGT_STRPBQ1JNN4, TGT_STRPCQ1JIT0, TGT_STRPD
Q1J8P1, TGT_STRPFA2RCC9, TGT_STRPGB1I9B4, TGT_STRPI
B8ZPB8, TGT_STRPJQ48VG9, TGT_STRPMP66907, TGT_STRPN
P0DF87, TGT_STRPQB2IMN3, TGT_STRPSB5XJL3, TGT_STRPZ
P66908, TGT_STRR6A4W2F8, TGT_STRS2C0MEV8, TGT_STRS7
A3CK60, TGT_STRSVA4VW51, TGT_STRSYQ5LY05, TGT_STRT1
Q5M2K9, TGT_STRT2Q03IQ5, TGT_STRTDB9DVZ9, TGT_STRU0
C1CGY8, TGT_STRZJC1CN05, TGT_STRZPC1CTW4, TGT_STRZT
Q30S46, TGT_SULDNA6Q906, TGT_SULNBQ67Q92, TGT_SYMTH
Q8GAA6, TGT_SYNE7A0LFR2, TGT_SYNFMQ0IDF3, TGT_SYNS3
Q3B088, TGT_SYNS9Q3AN18, TGT_SYNSCQ55983, TGT_SYNY3
B7IDU1, TGT_THEABA6LMW2, TGT_THEM4Q9X1P7, TGT_THEMA
B9K8N7, TGT_THENNA5IM22, TGT_THEP1B0K959, TGT_THEP3
B0K0M1, TGT_THEPXB1LB70, TGT_THESQQ72H19, TGT_THET2
Q5SLI7, TGT_THET8Q8CWM7, TGT_THEVBB5YHX4, TGT_THEYD
Q3SH61, TGT_THIDAB8GTQ4, TGT_THISHC4L7L3, TGT_TOLAT
Q73QK5, TGT_TREDEA1WFH2, TGT_VEREIA5CW46, TGT_VESOH
B7VJR8, TGT_VIBA3A7MT83, TGT_VIBC1A5F3H2, TGT_VIBC3
Q9KTY9, TGT_VIBCHC3LSZ4, TGT_VIBCMQ87S36, TGT_VIBPA
Q8DEY0, TGT_VIBVUQ7MNH1, TGT_VIBVYQ7M8N8, TGT_WOLSU
Q8PJL7, TGT_XANACQ3BS37, TGT_XANC5Q4UVX2, TGT_XANC8
B0RRR1, TGT_XANCBQ8P868, TGT_XANCPQ2P2X0, TGT_XANOM
B2SIN8, TGT_XANOPQ5GZY3, TGT_XANORB2I6T4, TGT_XYLF2
Q9PGS5, TGT_XYLFAB0U1P6, TGT_XYLFMQ87EW6, TGT_XYLFT
A1JNT0, TGT_YERE8A7FLF5, TGT_YERP3Q1C4H4, TGT_YERPA
B2K6S6, TGT_YERPBQ8ZC33, TGT_YERPEA9R351, TGT_YERPG
Q1CLA2, TGT_YERPNA4TPH6, TGT_YERPPQ66DW5, TGT_YERPS
B1JIE9, TGT_YERPYP28720, TGT_ZYMMO

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-