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ENZYME entry: EC 2.4.2.64

Accepted Name
tRNA-guanosine(34) queuine transglycosylase.
Alternative Name(s)
Guanine insertion enzyme.
Q-insertase.
Queuine tRNA-ribosyltransferase.
Queuine(34) transfer ribonucleate ribosyltransferase.
TGT.
tRNA transglycosylase.
Reaction catalysed
Guanine(34) in tRNA + queuine <=> queuine(34) in tRNA + guanine
Comment(s)
  • Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34.
  • In eukaryotes and a small number of prokaryotes queuine is salvaged and incorporated into tRNA directly via a base-exchange reaction, replacing guanine.
  • Cf. EC 2.4.2.29.
Cross-references
BRENDA2.4.2.64
EC2PDB2.4.2.64
ExplorEnz2.4.2.64
PRIAM enzyme-specific profiles2.4.2.64
KEGG Ligand Database for Enzyme Nomenclature2.4.2.64
IUBMB Enzyme Nomenclature2.4.2.64
IntEnz2.4.2.64
MEDLINEFind literature relating to 2.4.2.64
MetaCyc2.4.2.64
Rhea expert-curated reactions2.4.2.64
UniProtKB/Swiss-Prot
A8X0P0, TGT_CAEBR;  Q23623, TGT_CAEEL;  Q7SYK1, TGT_DANRE;  
Q9VPY8, TGT_DROME;  Q9BXR0, TGT_HUMAN;  Q9JMA2, TGT_MOUSE;  
Q4QR99, TGT_RAT;  O94460, TGT_SCHPO;  Q4QQY7, TGT_XENLA;  
Q28HC6, TGT_XENTR;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
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