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ENZYME

ENZYME entry: EC 2.4.2.64

PURL: https://purl.expasy.org/enzyme/EC/2.4.2.64
Accepted Name
tRNA-guanosine(34) queuine transglycosylase
Alternative Name(s)
guanine insertion enzyme
Q-insertase
queuine(34) transfer ribonucleate ribosyltransferase
queuine tRNA-ribosyltransferase
TGT
tRNA transglycosylase
Reaction catalysed
guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine
Comment(s)
  • Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34.
  • In eukaryotes and a small number of prokaryotes queuine is salvaged and incorporated into tRNA directly via a base-exchange reaction, replacing guanine. cf. EC 2.4.2.29.
Cross-references
BRENDA2.4.2.64
EC2PDB2.4.2.64
ExplorEnz2.4.2.64
KEGG Ligand Database for Enzyme Nomenclature2.4.2.64
IUBMB Enzyme Nomenclature2.4.2.64
MEDLINEFind literature relating to 2.4.2.64
MetaCyc2.4.2.64
Rhea expert-curated reactions2.4.2.64
UniProtKB/Swiss-Prot
A8X0P0, TGT_CAEBRQ23623, TGT_CAEELQ7SYK1, TGT_DANRE
Q9VPY8, TGT_DROMEQ9BXR0, TGT_HUMANQ9JMA2, TGT_MOUSE
Q4QR99, TGT_RATO94460, TGT_SCHPOQ4QQY7, TGT_XENLA
Q28HC6, TGT_XENTR

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-