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ENZYME entry: EC 2.4.2.36

Accepted Name
NAD(+)--diphthamide ADP-ribosyltransferase.
Alternative Name(s)
ADP-ribosyltransferase.
mono(ADP-ribosyl)transferase.
Reaction catalysed
diphthamide-[translation elongation factor 2] + NAD(+) <=> H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide
Comment(s)
  • Dihtheria toxin and some other bacterial toxins catalyze this reaction, which inactivates translation elongation factor 2 (EF2).
  • The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. cf. EC 2.4.2.31.
  • The relevant histidine of EF2 is His(715) in mammals, His(699) in yeast and His(600) in Pyrococcus horikoshii.
Cross-references
BRENDA2.4.2.36
EC2PDB2.4.2.36
ExplorEnz2.4.2.36
PRIAM enzyme-specific profiles2.4.2.36
KEGG Ligand Database for Enzyme Nomenclature2.4.2.36
IUBMB Enzyme Nomenclature2.4.2.36
IntEnz2.4.2.36
MEDLINEFind literature relating to 2.4.2.36
MetaCyc2.4.2.36
Rhea expert-curated reactions2.4.2.36
UniProtKB/Swiss-Prot
Q5EK40, CHXA_VIBCL;  P00588, DTX_CORBE;  P00587, DTX_COROM;  
P11439, TOXA_PSEAE;  

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