ENZYME entry: EC 2.4.2.36
Accepted Name |
NAD(+)--diphthamide ADP-ribosyltransferase.
|
Alternative Name(s) |
ADP-ribosyltransferase. |
mono(ADP-ribosyl)transferase. |
Reaction catalysed |
diphthamide-[translation elongation factor 2] + NAD(+) <=> H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide |
Comment(s) |
- Dihtheria toxin and some other bacterial toxins catalyze this
reaction, which inactivates translation elongation factor 2 (EF2).
- The acceptor is diphthamide, a unique modification of a histidine
residue in the elongation factor found in archaebacteria and all
eukaryotes, but not in eubacteria. cf. EC 2.4.2.31.
- The relevant histidine of EF2 is His(715) in mammals, His(699) in
yeast and His(600) in Pyrococcus horikoshii.
|
Cross-references |
BRENDA | 2.4.2.36 |
EC2PDB | 2.4.2.36 |
ExplorEnz | 2.4.2.36 |
PRIAM enzyme-specific profiles | 2.4.2.36 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.2.36 |
IUBMB Enzyme Nomenclature | 2.4.2.36 |
IntEnz | 2.4.2.36 |
MEDLINE | Find literature relating to 2.4.2.36 |
MetaCyc | 2.4.2.36 |
Rhea expert-curated reactions | 2.4.2.36 |
UniProtKB/Swiss-Prot |
|
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