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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.2.36

Accepted Name
NAD(+)--diphthamide ADP-ribosyltransferase.
Alternative Name(s)
ADP-ribosyltransferase.
Mono(ADP-ribosyl)transferase.
Reaction catalysed
NAD(+) + diphthamide-[translation elongation factor 2] <=> nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
Comment(s)
  • Dihtheria toxin and some other bacterial toxins catalyze this reaction, which inactivates translation elongation factor 2 (EF2).
  • The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria.
  • Cf. EC 2.4.2.31.
  • The relevant histidine of EF2 is His(715) in mammals, His(699) in yeast and His(600) in Pyrococcus horikoshii.
Cross-references
BRENDA2.4.2.36
EC2PDB2.4.2.36
ExplorEnz2.4.2.36
PRIAM enzyme-specific profiles2.4.2.36
KEGG Ligand Database for Enzyme Nomenclature2.4.2.36
IUBMB Enzyme Nomenclature2.4.2.36
IntEnz2.4.2.36
MEDLINEFind literature relating to 2.4.2.36
MetaCyc2.4.2.36
UniProtKB/Swiss-Prot
Q5EK40, CHXA_VIBCL;  P00588, DTX_CORBE;  P00587, DTX_COROM;  
P11439, TOXA_PSEAE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-