| Accepted Name |
|---|
| NAD(+)--protein-arginine ADP-ribosyltransferase.
|
| Alternative Name(s) |
|---|
| ADP-ribosyltransferase. |
| mono(ADP-ribosyl)transferase. |
| mono-ADP-ribosyltransferase. |
| NAD(P)(+)--arginine ADP-ribosyltransferase. |
| NAD(P)(+)--protein-arginine ADP-ribosyltransferase. |
| Reaction catalysed |
|---|
| L-arginyl-[protein] + NAD(+) <=> H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide |
| Comment(s) |
|---|
- Arginine residues in proteins act as acceptors.
- Free arginine, agmatine [(4-aminobutyl)guanidine], arginine methyl
ester and guanidine can also do so.
- The enzyme from some, but not all, species can also use NADP(+) as
acceptor (giving rise to N(omega)-[(2'-phospho-ADP)-D-ribosyl]-
protein-L-arginine as the product), but more slowly.
- Catalyzes the NAD(+)-dependent activation of EC 4.6.1.1.
- Some bacterial enterotoxins possess similar enzymatic activities (cf.
EC 2.4.2.36).
|
| Cross-references |
|---|
| BRENDA | 2.4.2.31 |
| EC2PDB | 2.4.2.31 |
| ExplorEnz | 2.4.2.31 |
| PRIAM enzyme-specific profiles | 2.4.2.31 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.2.31 |
| IUBMB Enzyme Nomenclature | 2.4.2.31 |
| IntEnz | 2.4.2.31 |
| MEDLINE | Find literature relating to 2.4.2.31 |
| MetaCyc | 2.4.2.31 |
| Rhea expert-curated reactions | 2.4.2.31 |
| UniProtKB/Swiss-Prot |
| Q38424, ALT_BPT2; | P12726, ALT_BPT4; | Q38433, ALT_BPT6; |
| A2PU44, CHELT_VIBCL; | Q838U8, EFV_ENTFA; | G3XDA1, EXOS_PSEAE; |
| Q9I788, EXOT_PSEAE; | Q5ZZ30, LART1_LEGPH; | A0QLI5, MAV_MYCA1; |
| P39421, MODA_BPT4; | P39423, MODB_BPT4; | P52961, NAR1_HUMAN; |
| Q60935, NAR1_MOUSE; | Q03515, NAR1_RABIT; | P17981, NAR2A_MOUSE; |
| P17982, NAR2A_RAT; | O35975, NAR2B_MOUSE; | P20974, NAR2B_RAT; |
| Q13508, NAR3_HUMAN; | Q8R2G4, NAR3_MOUSE; | Q93070, NAR4_HUMAN; |
| Q9CRA0, NAR4_MOUSE; | Q95NE0, NAR4_PANTR; | Q0VC22, NAR5_BOVIN; |
| Q96L15, NAR5_HUMAN; | P70352, NAR5_MOUSE; | Q5XHY4, NAR5_RAT; |
| Q92080, NARE_CHICK; | P55806, NRT1_CHICK; | P55807, NRT2_CHICK; |
| Q7N8B1, PHXA_PHOLL; | Q5ZTK4, SDEA_LEGPH; | Q5ZYX7, SIDE_LEGPH; |
| P17450, SPVB_SALCH; | P24419, SPVB_SALDU; | P55220, SPVB_SALEN; |
| D0ZHS9, SPVB_SALT1; | P21454, SPVB_SALTM; | B0KTG9, TRE1_PSEPG; |
| A8GG78, TRE1_SERP5; | A0KJB0, VGRG1_AERHH; | K7WKL8, VGRG1_AERHY; |
| A3UNN4, VIS_VIBS1; |
|