A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.4.2.31
| Accepted Name |
|---|
| NAD(+)--protein-arginine ADP-ribosyltransferase.
|
| Alternative Name(s) |
|---|
| ADP-ribosyltransferase. |
| Mono(ADP-ribosyl)transferase. |
| Mono-ADP-ribosyltransferase. |
| NAD(P)(+)--arginine ADP-ribosyltransferase. |
| NAD(P)(+)--protein-arginine ADP-ribosyltransferase. |
| Reaction catalysed |
|---|
| NAD(+) + protein-L-arginine <=> nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine |
| Comment(s) |
|---|
- Arginine residues in proteins act as acceptors.
- Free arginine, agmatine ((4-aminobutyl)guanidine), arginine methyl
ester and guanidine can also do so.
- The enzyme from some, but not all, species can also use NADP(+) as
acceptor (giving rise to N(omega)-((2'-phospho-ADP)-D-ribosyl)-
protein-L-arginine as the product), but more slowly.
- Catalyzes the NAD(+)-dependent activation of EC 4.6.1.1.
- Some bacterial enterotoxins possess similar enzymatic activities (cf.
EC 2.4.2.36).
|
| Cross-references |
|---|
| PROSITE | PDOC00993 |
| BRENDA | 2.4.2.31 |
| EC2PDB | 2.4.2.31 |
| ExplorEnz | 2.4.2.31 |
| PRIAM enzyme-specific profiles | 2.4.2.31 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.2.31 |
| IUBMB Enzyme Nomenclature | 2.4.2.31 |
| IntEnz | 2.4.2.31 |
| MEDLINE | Find literature relating to 2.4.2.31 |
| MetaCyc | 2.4.2.31 |
| UniProtKB/Swiss-Prot |
| A2PU44, CHELT_VIBCL; | Q838U8, EFV_ENTFA; | A0QLI5, MAV_MYCA1; |
| P52961, NAR1_HUMAN; | Q60935, NAR1_MOUSE; | Q03515, NAR1_RABIT; |
| P17981, NAR2A_MOUSE; | P17982, NAR2A_RAT; | O35975, NAR2B_MOUSE; |
| P20974, NAR2B_RAT; | Q13508, NAR3_HUMAN; | Q8R2G4, NAR3_MOUSE; |
| Q93070, NAR4_HUMAN; | Q9CRA0, NAR4_MOUSE; | Q95NE0, NAR4_PANTR; |
| Q0VC22, NAR5_BOVIN; | Q96L15, NAR5_HUMAN; | P70352, NAR5_MOUSE; |
| Q5XHY4, NAR5_RAT; | Q92080, NARE_CHICK; | P55806, NRT1_CHICK; |
| P55807, NRT2_CHICK; | Q7N8B1, PHXA_PHOLL; | Q5ZTK4, SDEA_LEGPH; |
| P17450, SPVB_SALCH; | P24419, SPVB_SALDU; | P55220, SPVB_SALEN; |
| D0ZHS9, SPVB_SALT1; | P21454, SPVB_SALTM; | A3UNN4, VIS_VIBS1; |
|
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