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ENZYME entry: EC 2.4.2.59

Accepted Name
Sulfide-dependent adenosine diphosphate thiazole synthase.
Reaction catalysed
NAD(+) + glycine + sulfide <=> nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H(2)O
Comment(s)
  • This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate.
  • The homologous enzyme from plants and fungi (EC 2.4.2.60) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme.
Cross-references
BRENDA2.4.2.59
EC2PDB2.4.2.59
ExplorEnz2.4.2.59
PRIAM enzyme-specific profiles2.4.2.59
KEGG Ligand Database for Enzyme Nomenclature2.4.2.59
IUBMB Enzyme Nomenclature2.4.2.59
IntEnz2.4.2.59
MEDLINEFind literature relating to 2.4.2.59
MetaCyc2.4.2.59
UniProtKB/Swiss-Prot
Q9Y9Z0, THI4_AERPE;  O29556, THI4_ARCFU;  C4XIR5, THI4_DESMR;  
A8ZVP3, THI4_DESOH;  A7HMY3, THI4_FERNB;  Q3V7Z9, THI4_HALMA;  
B0R884, THI4_HALS3;  Q9HMC7, THI4_HALSA;  Q18KP1, THI4_HALWD;  
A6UV59, THI4_META3;  Q8TM19, THI4_METAC;  Q46AR1, THI4_METBF;  
Q12U93, THI4_METBU;  F6BCS4, THI4_METIK;  Q58018, THI4_METJA;  
A4FWG7, THI4_METM5;  A9A9W1, THI4_METM6;  A6VGT9, THI4_METM7;  
Q8Q0B5, THI4_METMA;  A3CXS4, THI4_METMJ;  Q6LXJ8, THI4_METMP;  
A4YIV7, THI4_METS5;  O27657, THI4_METTH;  A0B880, THI4_METTP;  
A6UPZ7, THI4_METVS;  Q3IMI0, THI4_NATPD;  Q9V0J8, THI4_PYRAB;  
Q8ZZM5, THI4_PYRAE;  A4WKY7, THI4_PYRAR;  A3MWF6, THI4_PYRCJ;  
Q8U0Q5, THI4_PYRFU;  O59082, THI4_PYRHO;  A1RW13, THI4_PYRIL;  
B1YDX0, THI4_PYRNV;  Q97ZY5, THI4_SACS2;  Q4JAF8, THI4_SULAC;  
C3N6N6, THI4_SULIA;  C4KIA7, THI4_SULIK;  C3MQY1, THI4_SULIL;  
C3MWW9, THI4_SULIM;  C3NGI6, THI4_SULIN;  C3N749, THI4_SULIY;  
Q975R0, THI4_SULTO;  Q5JD25, THI4_THEKO;  Q9WZP4, THI4_THEMA;  

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