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ENZYME

ENZYME entry: EC 2.4.2.60

PURL: https://purl.expasy.org/enzyme/EC/2.4.2.60
Accepted Name
cysteine-dependent adenosine diphosphate thiazole synthase
Alternative Name(s)
ADP-thiazole synthase
Reaction catalysed
[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)
Comment(s)
  • This iron dependent enzyme, found in fungi, plants, and some archaea, is involved in the thiamine phosphate biosynthesis pathway.
  • It is a single turn-over enzyme since the cysteine residue is not regenerated in vivo.
  • The homologous enzyme in archaea (EC 2.4.2.59) uses sulfide as sulfur donor.
Cross-references
BRENDA2.4.2.60
EC2PDB2.4.2.60
ExplorEnz2.4.2.60
KEGG Ligand Database for Enzyme Nomenclature2.4.2.60
IUBMB Enzyme Nomenclature2.4.2.60
MEDLINEFind literature relating to 2.4.2.60
MetaCyc2.4.2.60
Rhea expert-curated reactions2.4.2.60
UniProtKB/Swiss-Prot
Q7XXS4, THI1_ORYSJQ41738, THI41_MAIZEA9RHX1, THI41_PHYPA
C5XNN6, THI41_SORBIF6H9A9, THI41_VITVIQ41739, THI42_MAIZE
A9SME1, THI42_PHYPAC5X2M4, THI42_SORBIF6H7K5, THI42_VITVI
A9RHW6, THI43_PHYPAA9SMC8, THI44_PHYPAQ9Y9Z0, THI4_AERPE
C0NSF3, THI4_AJECGQ38709, THI4_ALNGLQ38814, THI4_ARATH
Q4WMX7, THI4_ASPFUQ9UUZ9, THI4_ASPORQ5ANB7, THI4_CANAL
C4YNP4, THI4_CANAWA8J9T5, THI4_CHLREO23787, THI4_CITSI
A8NSD1, THI4_COPC7G5EAZ2, THI4_EMENIQ75F65, THI4_EREGS
J9N5G7, THI4_FUSO4P23618, THI4_FUSOXP23617, THI4_FUSSH
C7Z8P6, THI4_FUSV7Q3V7Z9, THI4_HALMAB0R884, THI4_HALS3
Q9HMC7, THI4_HALSAD4GSS5, THI4_HALVDQ18KP1, THI4_HALWD
Q4PC85, THI4_MYCMDQ3IMI0, THI4_NATPDQ1K6I4, THI4_NEUCR
Q0UQJ9, THI4_PHANOP84548, THI4_POPEUE3JV98, THI4_PUCGT
P40998, THI4_SCHPOA7EWL8, THI4_SCLS1Q9UVF8, THI4_UROFA
Q3V7I4, THI4_YARLIP32318, THI4_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-