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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.2.60

Accepted Name
Cysteine-dependent adenosine diphosphate thiazole synthase.
Alternative Name(s)
ADP-thiazole synthase.
Reaction catalysed
NAD(+) + glycine + [ADP-thiazole synthase]-L-cysteine <=> nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H(2)O
Comment(s)
  • This iron dependent enzyme, found in fungi, plants, and some archaea, is involved in the thiamine phosphate biosynthesis pathway.
  • It is a single turn-over enzyme since the cysteine residue is not regenerated in vivo.
  • The homologous enzyme in archaea (EC 2.4.2.59) uses sulfide as sulfur donor.
Cross-references
BRENDA2.4.2.60
EC2PDB2.4.2.60
ExplorEnz2.4.2.60
PRIAM enzyme-specific profiles2.4.2.60
KEGG Ligand Database for Enzyme Nomenclature2.4.2.60
IUBMB Enzyme Nomenclature2.4.2.60
IntEnz2.4.2.60
MEDLINEFind literature relating to 2.4.2.60
MetaCyc2.4.2.60
UniProtKB/Swiss-Prot
Q41738, THI41_MAIZE;  A9RHX1, THI41_PHYPA;  C5XNN6, THI41_SORBI;  
F6H9A9, THI41_VITVI;  Q41739, THI42_MAIZE;  A9SME1, THI42_PHYPA;  
C5X2M4, THI42_SORBI;  F6H7K5, THI42_VITVI;  A9RHW6, THI43_PHYPA;  
A9SMC8, THI44_PHYPA;  C0NSF3, THI4_AJECG;  Q38709, THI4_ALNGL;  
Q38814, THI4_ARATH;  Q75F65, THI4_ASHGO;  Q4WMX7, THI4_ASPFU;  
Q9UUZ9, THI4_ASPOR;  Q5ANB7, THI4_CANAL;  C4YNP4, THI4_CANAW;  
A8J9T5, THI4_CHLRE;  O23787, THI4_CITSI;  A8NSD1, THI4_COPC7;  
G5EAZ2, THI4_EMENI;  J9N5G7, THI4_FUSO4;  P23618, THI4_FUSOX;  
P23617, THI4_FUSSH;  C7Z8P6, THI4_NECH7;  Q1K6I4, THI4_NEUCR;  
Q0UQJ9, THI4_PHANO;  P84548, THI4_POPEU;  E3JV98, THI4_PUCGT;  
P40998, THI4_SCHPO;  A7EWL8, THI4_SCLS1;  Q9UVF8, THI4_UROFA;  
Q4PC85, THI4_USTMA;  Q3V7I4, THI4_YARLI;  P32318, THI4_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-