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ENZYME entry: EC 2.4.3.7

Accepted Name
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase.
Alternative Name(s)
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase.
cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta- galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase.
NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase.
sialyltransferase.
ST6GALNAC.
Reaction catalysed
an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)
Comment(s)
  • Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetylgalactosamine only when present in the structure of alpha-N- acetylneuraminyl-(2->3)-beta-galactosyl-(1->3)-N- acetylgalactosaminyl-R, where R may be protein or p-nitrophenol.
  • Not identical with EC 2.4.3.3.
  • Formerly EC 2.4.99.7.
Cross-references
BRENDA2.4.3.7
EC2PDB2.4.3.7
ExplorEnz2.4.3.7
PRIAM enzyme-specific profiles2.4.3.7
KEGG Ligand Database for Enzyme Nomenclature2.4.3.7
IUBMB Enzyme Nomenclature2.4.3.7
IntEnz2.4.3.7
MEDLINEFind literature relating to 2.4.3.7
MetaCyc2.4.3.7
Rhea expert-curated reactions2.4.3.7
UniProtKB/Swiss-Prot
Q8NDV1, SIA7C_HUMAN;  Q9WUV2, SIA7C_MOUSE;  Q64686, SIA7C_RAT;  
Q9H4F1, SIA7D_HUMAN;  Q9R2B6, SIA7D_MOUSE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.3.-
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