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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Dolichyl-diphosphooligosaccharide--protein glycotransferase.
Reaction catalysed
Dolichyl diphosphooligosaccharide + [protein]-L-asparagine <=> dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine
  • Occurs in eukaryotes that form a glycoprotein by the transfer of a glucosyl-mannosyl-glucosamine polysaccharide to the side-chain of an L-asparagine residue in the sequence -Asn-Xaa-Ser- or -Asn-Xaa-Thr- (Xaa not Pro) in nascent polypeptide chains.
  • The basic oligosaccharide is the tetradecasaccharide Glc(3)Man(9)GlcNAc(2).
  • However, smaller oligosaccharides derived from it and oligosaccharides with additional monosaccharide units attached may be involved.
  • Man(3)GlcNAc(2) seems to be common for all of the oligosaccharides involved with the terminal N-acetylglucosamine linked to the protein L-asparagine.
  • Occurs on the cytosolic face of the endoplasmic reticulum.
  • The dolichol involved normally has 14-21 isoprenoid units with two trans double-bonds at the omega end, and the rest of the double-bonds in cis form.
  • Formerly EC
PRIAM enzyme-specific profiles2.4.99.18
KEGG Ligand Database for Enzyme Nomenclature2.4.99.18
IUBMB Enzyme Nomenclature2.4.99.18
MEDLINEFind literature relating to
P46977, STT3A_HUMAN;  P46978, STT3A_MOUSE;  Q6F2Z1, STT3A_ORYSJ;  
P46975, STT3_CAEEL;  Q54NM9, STT3_DICDI;  O94335, STT3_SCHPO;  
P39007, STT3_YEAST;  

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