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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.99.2

Accepted Name
Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase.
Alternative Name(s)
Monosialoganglioside sialyltransferase.
Reaction catalysed
CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R <=> CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R
Comment(s)
  • The enzyme recognizes the sequence beta-D-galactosyl-(1->3)-N-acetyl- D-galactosaminyl (known as type 1 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
  • When acting on gangloside GM1a, it forms gangloside GD1a.
Cross-references
BRENDA2.4.99.2
EC2PDB2.4.99.2
ExplorEnz2.4.99.2
PRIAM enzyme-specific profiles2.4.99.2
KEGG Ligand Database for Enzyme Nomenclature2.4.99.2
IUBMB Enzyme Nomenclature2.4.99.2
IntEnz2.4.99.2
MEDLINEFind literature relating to 2.4.99.2
MetaCyc2.4.99.2
UniProtKB/Swiss-Prot
Q11206, SIA4C_HUMAN;  Q91Y74, SIA4C_MOUSE;  P61130, SIA4C_PANTR;  
P61131, SIA4C_RAT;  

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