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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase.
Alternative Name(s)
Diphosphopyridine nucleosidase.
Reaction catalysed
NADP(+) + nicotinate <=> nicotinate-adenine dinucleotide phosphate + nicotinamide
  • This multiunctional enzyme catalyzes both the removal of nicotinamide from NADP(+), forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP(+), a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes.
  • In addition, the enzyme also catalyzes EC
PRIAM enzyme-specific profiles2.4.99.20
KEGG Ligand Database for Enzyme Nomenclature2.4.99.20
IUBMB Enzyme Nomenclature2.4.99.20
MEDLINEFind literature relating to
P28907, CD38_HUMAN;  Q5VAN0, CD38_MACFA;  P56528, CD38_MOUSE;  
Q9MZ03, CD38_RABIT;  Q64244, CD38_RAT;  P29241, NADA_APLCA;  
Q27312, NADA_APLKU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.99.-
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