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ENZYME entry: EC 2.4.99.20

Accepted Name
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase.
Alternative Name(s)
Diphosphopyridine nucleosidase.
Reaction catalysed
NADP(+) + nicotinate <=> nicotinate-adenine dinucleotide phosphate + nicotinamide
Comment(s)
  • This multiunctional enzyme catalyzes both the removal of nicotinamide from NADP(+), forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP(+), a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes.
  • In addition, the enzyme also catalyzes EC 3.2.2.6.
Cross-references
BRENDA2.4.99.20
EC2PDB2.4.99.20
ExplorEnz2.4.99.20
PRIAM enzyme-specific profiles2.4.99.20
KEGG Ligand Database for Enzyme Nomenclature2.4.99.20
IUBMB Enzyme Nomenclature2.4.99.20
IntEnz2.4.99.20
MEDLINEFind literature relating to 2.4.99.20
MetaCyc2.4.99.20
Rhea expert-curated reactions2.4.99.20
UniProtKB/Swiss-Prot
P28907, CD38_HUMAN;  Q5VAN0, CD38_MACFA;  P56528, CD38_MOUSE;  
Q9MZ03, CD38_RABIT;  Q64244, CD38_RAT;  P29241, NADA_APLCA;  
Q27312, NADA_APLKU;  

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