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ENZYME entry: EC 2.4.99.20
Accepted Name |
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase.
|
Alternative Name(s) |
diphosphopyridine nucleosidase. |
Reaction catalysed |
NADP(+) + nicotinate <=> nicotinamide + nicotinate-adenine dinucleotide phosphate |
Comment(s) |
- This multiunctional enzyme catalyzes both the removal of nicotinamide
from NADP(+), forming 2'-phospho-cyclic ADP-ribose, and the addition
of nicotinate to the cyclic product, forming NAADP(+), a calcium
messenger that can mobilize intracellular Ca(2+) stores and activate
Ca(2+) influx to regulate a wide range of physiological processes.
- In addition, the enzyme also catalyzes EC 3.2.2.6.
|
Cross-references |
BRENDA | 2.4.99.20 |
EC2PDB | 2.4.99.20 |
ExplorEnz | 2.4.99.20 |
PRIAM enzyme-specific profiles | 2.4.99.20 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.99.20 |
IUBMB Enzyme Nomenclature | 2.4.99.20 |
IntEnz | 2.4.99.20 |
MEDLINE | Find literature relating to 2.4.99.20 |
MetaCyc | 2.4.99.20 |
Rhea expert-curated reactions | 2.4.99.20 |
UniProtKB/Swiss-Prot |
|
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