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ENZYME

ENZYME entry: EC 3.2.2.6

Accepted Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Alternative Name(s)
NAD(+) nucleosidase
NADase
NAD hydrolase
nicotinamide adenine dinucleotide nucleosidase
Reaction catalysed
H2O + NAD(+) <=> ADP-D-ribose + H(+) + nicotinamide
Comment(s)
  • This multiunctional enzyme catalyzes both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes.
  • In addition, the enzyme also catalyzes EC 2.4.99.20.
  • It is also able to act on beta-nicotinamide D-ribonucleotide. cf. EC 3.2.2.5.
Cross-references
BRENDA3.2.2.6
EC2PDB3.2.2.6
ExplorEnz3.2.2.6
PRIAM enzyme-specific profiles3.2.2.6
KEGG Ligand Database for Enzyme Nomenclature3.2.2.6
IUBMB Enzyme Nomenclature3.2.2.6
IntEnz3.2.2.6
MEDLINEFind literature relating to 3.2.2.6
MetaCyc3.2.2.6
Rhea expert-curated reactions3.2.2.6
UniProtKB/Swiss-Prot
A0A009IHW8, ABTIR_ACIB9Q9C7X0, ADR2_ARATHG8SD34, APTIR_ACTS5
I1GTC2, BDTIR_BRADIQ10588, BST1_HUMANQ64277, BST1_MOUSE
Q63072, BST1_RATP28907, CD38_HUMANQ5VAN0, CD38_MACFA
P56528, CD38_MOUSEQ9MZ03, CD38_RABITQ64244, CD38_RAT
Q9LUJ8, CHL1_ARATHF4I902, CHS1_ARATHF4KIF3, CSA1_ARATH
Q9SZ66, DSC1_ARATHF4JWM0, DSC2_ARATHO95256, I18RA_HUMAN
Q9Z2B1, I18RA_MOUSEQ13478, IL18R_HUMANQ61098, IL18R_MOUSE
Q9NPH3, IL1AP_HUMANP59822, IL1AP_MACMUQ61730, IL1AP_MOUSE
Q63621, IL1AP_RATP14778, IL1R1_HUMANP13504, IL1R1_MOUSE
Q02955, IL1R1_RATQ01638, ILRL1_HUMANP14719, ILRL1_MOUSE
Q62611, ILRL1_RATQ9HB29, ILRL2_HUMANQ9ERS7, ILRL2_MOUSE
Q62929, ILRL2_RATB6ZK76, IRL1A_DANREB6ZK77, IRL1B_DANRE
Q9NZN1, IRPL1_HUMANP59823, IRPL1_MOUSEP60029, IRPL1_PANTR
Q7YQL9, IRPL1_PONPYP59824, IRPL1_RATQ9NP60, IRPL2_HUMAN
Q9ERS6, IRPL2_MOUSEQ40253, L6_LINUSO48573, LAZ5_ARATH
Q27312, NADA_APLKUQ9C5Q9, P2A05_ARATHQ9FHE8, P2A06_ARATH
Q9FHE9, P2A08_ARATHA1AY86, PDTIR_PARDPF4HT77, RBA1_ARATH
F4I594, RLM1A_ARATHQ9CAK1, RLM1B_ARATHQ9FT77, RLM3_ARATH
A0A290U7C4, ROQ1_NICBEF4J339, RPP1_ARATHF4JT78, RPP2A_ARATH
F4JT80, RPP2B_ARATHF4JT82, RPP2C_ARATHO49471, RPP2D_ARATH
F4JNA9, RPP4_ARATHF4JNB7, RPP5_ARATHQ9FHF0, RPS4B_ARATH
Q9SCX6, RPS4L_ARATHQ9SCX7, RPS4R_ARATHC4B7M7, RPS4W_ARATH
Q9XGM3, RPS4_ARATHF4KHH8, RPS6C_ARATHP0DKH6, RPS6R_ARATH
V9M2S5, RPV1_VITROV9M398, RUN1_VITROQ86DA5, SARM1_CAEEL
F1QWA8, SARM1_DANREQ6IDD9, SARM1_DROMEQ6SZW1, SARM1_HUMAN
Q6PDS3, SARM1_MOUSEI3L5V6, SARM1_PIGD3ZUM2, SARM1_RAT
O23530, SNC1_ARATHP0DUE1, STING_CRAGIQ9FI14, TAO1_ARATH
A0A151EH88, TCPA_THEADQ2YPC4, TCPB_BRUA2C0RGW8, TCPB_BRUMB
Q8YF53, TCPB_BRUMEA0A0H2V8B5, TCPC_ECOL6Q833J1, TCPF_ENTFA
A0A1I4KS07, TCPO_METOLQ0WSX8, TIK_ARATHQ54HT1, TIRA_DICDI
P0DTS9, TIRS_STAASQ40392, TMVRN_NICGUQ9SYC9, VAP14_ARATH
F4KHI3, VICTR_ARATHO82500, Y4117_ARATHP96648, YDDK_BACSU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-