ENZYME entry: EC 3.2.2.6

PURL: https://purl.expasy.org/enzyme/EC/3.2.2.6

Accepted Name

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

Alternative Name(s)

NAD(+) nucleosidase

NADase

NAD hydrolase

nicotinamide adenine dinucleotide nucleosidase

Reaction catalysed

NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)

Comment(s)

This multiunctional enzyme catalyzes both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes.
In addition, the enzyme also catalyzes EC 2.4.99.20.
It is also able to act on beta-nicotinamide D-ribonucleotide. cf. EC 3.2.2.5.

Cross-references

BRENDA

3.2.2.6

EC2PDB

3.2.2.6

ExplorEnz

3.2.2.6

KEGG Ligand Database for Enzyme Nomenclature

3.2.2.6

IUBMB Enzyme Nomenclature

3.2.2.6

MEDLINE

Find literature relating to 3.2.2.6

MetaCyc

3.2.2.6

Rhea expert-curated reactions

3.2.2.6

UniProtKB/Swiss-Prot

A0A009IHW8, ABTIR_ACIB9	Q9C7X0, ADR2_ARATH	G8SD34, APTIR_ACTS5
I1GTC2, BDTIR_BRADI	Q10588, BST1_HUMAN	Q64277, BST1_MOUSE
Q63072, BST1_RAT	P28907, CD38_HUMAN	Q5VAN0, CD38_MACFA
P56528, CD38_MOUSE	Q9MZ03, CD38_RABIT	Q64244, CD38_RAT
Q9LUJ8, CHL1_ARATH	F4I902, CHS1_ARATH	F4KIF3, CSA1_ARATH
Q9SZ66, DSC1_ARATH	F4JWM0, DSC2_ARATH	O95256, I18RA_HUMAN
Q9Z2B1, I18RA_MOUSE	Q13478, IL18R_HUMAN	Q61098, IL18R_MOUSE
Q9NPH3, IL1AP_HUMAN	P59822, IL1AP_MACMU	Q61730, IL1AP_MOUSE
Q63621, IL1AP_RAT	P14778, IL1R1_HUMAN	P13504, IL1R1_MOUSE
Q02955, IL1R1_RAT	Q01638, ILRL1_HUMAN	P14719, ILRL1_MOUSE
Q62611, ILRL1_RAT	Q9HB29, ILRL2_HUMAN	Q9ERS7, ILRL2_MOUSE
Q62929, ILRL2_RAT	B6ZK76, IRL1A_DANRE	B6ZK77, IRL1B_DANRE
Q9NZN1, IRPL1_HUMAN	P59823, IRPL1_MOUSE	P60029, IRPL1_PANTR
Q7YQL9, IRPL1_PONPY	P59824, IRPL1_RAT	Q9NP60, IRPL2_HUMAN
Q9ERS6, IRPL2_MOUSE	Q40253, L6_LINUS	O48573, LAZ5_ARATH
Q27312, NADA_APLKU	Q9C5Q9, P2A05_ARATH	Q9FHE8, P2A06_ARATH
Q9FHE9, P2A08_ARATH	A1AY86, PDTIR_PARDP	F4HT77, RBA1_ARATH
F4I594, RLM1A_ARATH	Q9CAK1, RLM1B_ARATH	Q9FT77, RLM3_ARATH
A0A290U7C4, ROQ1_NICBE	F4J339, RPP1_ARATH	F4JT78, RPP2A_ARATH
F4JT80, RPP2B_ARATH	F4JT82, RPP2C_ARATH	O49471, RPP2D_ARATH
F4JNA9, RPP4_ARATH	F4JNB7, RPP5_ARATH	Q9FHF0, RPS4B_ARATH
Q9SCX6, RPS4L_ARATH	Q9SCX7, RPS4R_ARATH	C4B7M7, RPS4W_ARATH
Q9XGM3, RPS4_ARATH	F4KHH8, RPS6C_ARATH	P0DKH6, RPS6R_ARATH
V9M2S5, RPV1_VITRO	V9M398, RUN1_VITRO	Q86DA5, SARM1_CAEEL
F1QWA8, SARM1_DANRE	Q6IDD9, SARM1_DROME	Q6SZW1, SARM1_HUMAN
Q6PDS3, SARM1_MOUSE	I3L5V6, SARM1_PIG	D3ZUM2, SARM1_RAT
O23530, SNC1_ARATH	P0DUE1, STING_MAGGI	Q9FI14, TAO1_ARATH
A0A151EH88, TCPA_THEAD	Q2YPC4, TCPB_BRUA2	C0RGW8, TCPB_BRUMB
Q8YF53, TCPB_BRUME	A0A0H2V8B5, TCPC_ECOL6	Q833J1, TCPF_ENTFA
A0A1I4KS07, TCPO_METOL	Q0WSX8, TIK_ARATH	Q54HT1, TIRA_DICDI
P0DTS9, TIRS_STAAS	Q40392, TMVRN_NICGU	Q9SYC9, VAP14_ARATH
F4KHI3, VICTR_ARATH	O82500, Y4117_ARATH	P96648, YDDK_BACSU

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