Home  |  Contact

ENZYME entry: EC 3.2.2.6

Accepted Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
Alternative Name(s)
NAD hydrolase.
NAD(+) nucleosidase.
NADase.
Nicotinamide adenine dinucleotide nucleosidase.
Reaction catalysed
NAD(+) + H(2)O <=> ADP-D-ribose + nicotinamide
Comment(s)
  • This multiunctional enzyme catalyzes both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes.
  • In addition, the enzyme also catalyzes EC 2.4.99.20.
  • It is also able to act on beta-nicotinamide D-ribonucleotide.
  • Cf. EC 3.2.2.5.
Cross-references
BRENDA3.2.2.6
EC2PDB3.2.2.6
ExplorEnz3.2.2.6
PRIAM enzyme-specific profiles3.2.2.6
KEGG Ligand Database for Enzyme Nomenclature3.2.2.6
IUBMB Enzyme Nomenclature3.2.2.6
IntEnz3.2.2.6
MEDLINEFind literature relating to 3.2.2.6
MetaCyc3.2.2.6
UniProtKB/Swiss-Prot
A0A009IHW8, ABTIR_ACIB9;  Q9C7X0, ADR2_ARATH;  G8SD34, APTIR_ACTS5;  
Q10588, BST1_HUMAN;  Q64277, BST1_MOUSE;  Q63072, BST1_RAT;  
C0RGW8, BTPA_BRUMB;  P28907, CD38_HUMAN;  Q5VAN0, CD38_MACFA;  
P56528, CD38_MOUSE;  Q9MZ03, CD38_RABIT;  Q64244, CD38_RAT;  
Q9LUJ8, CHL1_ARATH;  F4I902, CHS1_ARATH;  F4KIF3, CSA1_ARATH;  
Q9SZ66, DSC1_ARATH;  F4JWM0, DSC2_ARATH;  O95256, I18RA_HUMAN;  
Q9Z2B1, I18RA_MOUSE;  Q13478, IL18R_HUMAN;  Q61098, IL18R_MOUSE;  
Q9NPH3, IL1AP_HUMAN;  P59822, IL1AP_MACMU;  Q61730, IL1AP_MOUSE;  
Q63621, IL1AP_RAT;  P14778, IL1R1_HUMAN;  P13504, IL1R1_MOUSE;  
Q02955, IL1R1_RAT;  Q01638, ILRL1_HUMAN;  P14719, ILRL1_MOUSE;  
Q62611, ILRL1_RAT;  Q9HB29, ILRL2_HUMAN;  Q9ERS7, ILRL2_MOUSE;  
Q62929, ILRL2_RAT;  B6ZK76, IRL1A_DANRE;  B6ZK77, IRL1B_DANRE;  
Q9NZN1, IRPL1_HUMAN;  P59823, IRPL1_MOUSE;  P60029, IRPL1_PANTR;  
Q7YQL9, IRPL1_PONPY;  P59824, IRPL1_RAT;  Q9NP60, IRPL2_HUMAN;  
Q9ERS6, IRPL2_MOUSE;  Q40253, L6_LINUS;  O48573, LAZ5_ARATH;  
P29241, NADA_APLCA;  Q27312, NADA_APLKU;  Q9C5Q9, P2A05_ARATH;  
Q9FHE8, P2A06_ARATH;  Q9FHE9, P2A08_ARATH;  A1AY86, PDTIR_PARDP;  
F4HT77, RBA1_ARATH;  F4I594, RLM1A_ARATH;  Q9CAK1, RLM1B_ARATH;  
Q9FT77, RLM3_ARATH;  A0A290U7C4, ROQ1_NICBE;  F4J339, RPP1_ARATH;  
F4JT78, RPP2A_ARATH;  F4JT80, RPP2B_ARATH;  F4JT82, RPP2C_ARATH;  
O49471, RPP2D_ARATH;  F4JNA9, RPP4_ARATH;  F4JNB7, RPP5_ARATH;  
Q9FHF0, RPS4B_ARATH;  Q9SCX6, RPS4L_ARATH;  Q9SCX7, RPS4R_ARATH;  
C4B7M7, RPS4W_ARATH;  Q9XGM3, RPS4_ARATH;  F4KHH8, RPS6C_ARATH;  
P0DKH6, RPS6R_ARATH;  V9M2S5, RPV1_VITRO;  V9M398, RUN1_VITRO;  
Q86DA5, SARM1_CAEEL;  F1QWA8, SARM1_DANRE;  Q6IDD9, SARM1_DROME;  
Q6SZW1, SARM1_HUMAN;  Q6PDS3, SARM1_MOUSE;  I3L5V6, SARM1_PIG;  
O23530, SNC1_ARATH;  Q9FI14, TAO1_ARATH;  A0A151EH88, TCPA_THEAD;  
A0A0H2V8B5, TCPC_ECOL6;  Q833J1, TCPF_ENTFA;  A0A1I4KS07, TCPO_METOL;  
Q0WSX8, TIK_ARATH;  Q54HT1, TIRA_DICDI;  P0DTS9, TIRS_STAAS;  
Q9SSN3, TIR_ARATH;  I1GTC2, TIR_BRADI;  Q6GV17, TLR10_BOVIN;  
Q9BXR5, TLR10_HUMAN;  Q6R5P0, TLR11_MOUSE;  Q6QNU9, TLR12_MOUSE;  
Q6R5N8, TLR13_MOUSE;  Q15399, TLR1_HUMAN;  Q9EPQ1, TLR1_MOUSE;  
Q9DD78, TLR21_CHICK;  Q9DGB6, TLR22_CHICK;  B2LT61, TLR2_BISBI;  
B5T267, TLR2_BOSIN;  Q2V897, TLR2_BOSTR;  Q95LA9, TLR2_BOVIN;  
Q2PZH4, TLR2_BUBBU;  Q689D1, TLR2_CANLF;  Q0GC71, TLR2_CAPHI;  
B2LT62, TLR2_CAPIB;  Q9R1F8, TLR2_CRIGR;  B2LT64, TLR2_GIRCA;  
B3Y615, TLR2_GORGO;  Q6T752, TLR2_HORSE;  O60603, TLR2_HUMAN;  
Q95M53, TLR2_MACFA;  B3Y618, TLR2_MACMU;  Q9QUN7, TLR2_MOUSE;  
B3Y614, TLR2_PANPA;  B3Y613, TLR2_PANTR;  B2LT65, TLR2_SHEEP;  
Q2V898, TLR4_BOSTR;  Q9GL65, TLR4_BOVIN;  Q9WV82, TLR4_CRIGR;  
P58727, TLR4_FELCA;  Q8SPE8, TLR4_GORGO;  Q9MYW3, TLR4_HORSE;  
O00206, TLR4_HUMAN;  Q9QUK6, TLR4_MOUSE;  Q9TTN0, TLR4_PANPA;  
Q9TSP2, TLR4_PAPAN;  Q68Y56, TLR4_PIG;  V5NAL9, TLR4_PINIB;  
Q8SPE9, TLR4_PONPY;  Q9QX05, TLR4_RAT;  Q704V6, TLR6_BOVIN;  
Q0ZUL9, TLR6_DASNO;  Q9Y2C9, TLR6_HUMAN;  Q9EPW9, TLR6_MOUSE;  
Q40392, TMVRN_NICGU;  Q9VUN0, TOLL6_DROME;  Q7KIN0, TOLL7_DROME;  
Q9V477, TOLL8_DROME;  P08953, TOLL_DROME;  Q9SYC9, VAP14_ARATH;  
F4KHI3, VICTR_ARATH;  O82500, Y4117_ARATH;  P96648, YDDK_BACSU;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-