ENZYME entry: EC 3.2.2.6

Accepted Name

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

Alternative Name(s)

NAD(+) nucleosidase

NADase

NAD hydrolase

nicotinamide adenine dinucleotide nucleosidase

Reaction catalysed

H2O + NAD(+) <=> ADP-D-ribose + H(+) + nicotinamide

Comment(s)

This multiunctional enzyme catalyzes both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes.
In addition, the enzyme also catalyzes EC 2.4.99.20.
It is also able to act on beta-nicotinamide D-ribonucleotide. cf. EC 3.2.2.5.

Cross-references

BRENDA

3.2.2.6

EC2PDB

3.2.2.6

ExplorEnz

3.2.2.6

PRIAM enzyme-specific profiles

3.2.2.6

KEGG Ligand Database for Enzyme Nomenclature

3.2.2.6

IUBMB Enzyme Nomenclature

3.2.2.6

IntEnz

3.2.2.6

MEDLINE

Find literature relating to 3.2.2.6

MetaCyc

3.2.2.6

Rhea expert-curated reactions

3.2.2.6

UniProtKB/Swiss-Prot

A0A009IHW8, ABTIR_ACIB9	Q9C7X0, ADR2_ARATH	G8SD34, APTIR_ACTS5
Q10588, BST1_HUMAN	Q64277, BST1_MOUSE	Q63072, BST1_RAT
C0RGW8, BTPA_BRUMB	P28907, CD38_HUMAN	Q5VAN0, CD38_MACFA
P56528, CD38_MOUSE	Q9MZ03, CD38_RABIT	Q64244, CD38_RAT
Q9LUJ8, CHL1_ARATH	F4I902, CHS1_ARATH	F4KIF3, CSA1_ARATH
Q9SZ66, DSC1_ARATH	F4JWM0, DSC2_ARATH	O95256, I18RA_HUMAN
Q9Z2B1, I18RA_MOUSE	Q13478, IL18R_HUMAN	Q61098, IL18R_MOUSE
Q9NPH3, IL1AP_HUMAN	P59822, IL1AP_MACMU	Q61730, IL1AP_MOUSE
Q63621, IL1AP_RAT	P14778, IL1R1_HUMAN	P13504, IL1R1_MOUSE
Q02955, IL1R1_RAT	Q01638, ILRL1_HUMAN	P14719, ILRL1_MOUSE
Q62611, ILRL1_RAT	Q9HB29, ILRL2_HUMAN	Q9ERS7, ILRL2_MOUSE
Q62929, ILRL2_RAT	B6ZK76, IRL1A_DANRE	B6ZK77, IRL1B_DANRE
Q9NZN1, IRPL1_HUMAN	P59823, IRPL1_MOUSE	P60029, IRPL1_PANTR
Q7YQL9, IRPL1_PONPY	P59824, IRPL1_RAT	Q9NP60, IRPL2_HUMAN
Q9ERS6, IRPL2_MOUSE	Q40253, L6_LINUS	O48573, LAZ5_ARATH
P29241, NADA_APLCA	Q27312, NADA_APLKU	Q9C5Q9, P2A05_ARATH
Q9FHE8, P2A06_ARATH	Q9FHE9, P2A08_ARATH	A1AY86, PDTIR_PARDP
F4HT77, RBA1_ARATH	F4I594, RLM1A_ARATH	Q9CAK1, RLM1B_ARATH
Q9FT77, RLM3_ARATH	A0A290U7C4, ROQ1_NICBE	F4J339, RPP1_ARATH
F4JT78, RPP2A_ARATH	F4JT80, RPP2B_ARATH	F4JT82, RPP2C_ARATH
O49471, RPP2D_ARATH	F4JNA9, RPP4_ARATH	F4JNB7, RPP5_ARATH
Q9FHF0, RPS4B_ARATH	Q9SCX6, RPS4L_ARATH	Q9SCX7, RPS4R_ARATH
C4B7M7, RPS4W_ARATH	Q9XGM3, RPS4_ARATH	F4KHH8, RPS6C_ARATH
P0DKH6, RPS6R_ARATH	V9M2S5, RPV1_VITRO	V9M398, RUN1_VITRO
Q86DA5, SARM1_CAEEL	F1QWA8, SARM1_DANRE	Q6IDD9, SARM1_DROME
Q6SZW1, SARM1_HUMAN	Q6PDS3, SARM1_MOUSE	I3L5V6, SARM1_PIG
D3ZUM2, SARM1_RAT	O23530, SNC1_ARATH	P0DUE1, STING_CRAGI
Q9FI14, TAO1_ARATH	A0A151EH88, TCPA_THEAD	A0A0H2V8B5, TCPC_ECOL6
Q833J1, TCPF_ENTFA	A0A1I4KS07, TCPO_METOL	Q0WSX8, TIK_ARATH
Q54HT1, TIRA_DICDI	P0DTS9, TIRS_STAAS	I1GTC2, TIR_BRADI
Q40392, TMVRN_NICGU	Q9SYC9, VAP14_ARATH	F4KHI3, VICTR_ARATH
O82500, Y4117_ARATH	P96648, YDDK_BACSU

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