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ENZYME entry: EC 2.4.99.22

Accepted Name
N-acetylglucosaminide alpha-(2,6)-sialyltransferase.
Alternative Name(s)
Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylglucosaminide 6-alpha-sialyltransferase.
N-acetylglucosaminide (alpha 2->6)-sialyltransferase.
Reaction catalysed
CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R <=> CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-(N-acetyl-alpha-neuraminyl-(2->6))-N-acetyl-beta-D-glucosaminyl-R
Comment(s)
  • Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl- beta-D-glucosamine.
  • The enzyme from rat liver also acts on beta-D-galactosyl-(1->3)-N- acetyl-beta-D-glucosaminyl residues, but more slowly.
Cross-references
BRENDA2.4.99.22
EC2PDB2.4.99.22
ExplorEnz2.4.99.22
PRIAM enzyme-specific profiles2.4.99.22
KEGG Ligand Database for Enzyme Nomenclature2.4.99.22
IUBMB Enzyme Nomenclature2.4.99.22
IntEnz2.4.99.22
MEDLINEFind literature relating to 2.4.99.22
MetaCyc2.4.99.22
Rhea expert-curated reactions2.4.99.22

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