ENZYME entry: EC 2.4.99.22
| Accepted Name |
|---|
| N-acetylglucosaminide alpha-(2,6)-sialyltransferase.
|
| Alternative Name(s) |
|---|
| Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylglucosaminide
6-alpha-sialyltransferase. |
| N-acetylglucosaminide (alpha 2->6)-sialyltransferase. |
| Reaction catalysed |
|---|
| CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R <=> CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-(N-acetyl-alpha-neuraminyl-(2->6))-N-acetyl-beta-D-glucosaminyl-R |
| Comment(s) |
|---|
- Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-
beta-D-glucosamine.
- The enzyme from rat liver also acts on beta-D-galactosyl-(1->3)-N-
acetyl-beta-D-glucosaminyl residues, but more slowly.
|
| Cross-references |
|---|
| BRENDA | 2.4.99.22 |
| EC2PDB | 2.4.99.22 |
| ExplorEnz | 2.4.99.22 |
| PRIAM enzyme-specific profiles | 2.4.99.22 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.99.22 |
| IUBMB Enzyme Nomenclature | 2.4.99.22 |
| IntEnz | 2.4.99.22 |
| MEDLINE | Find literature relating to 2.4.99.22 |
| MetaCyc | 2.4.99.22 |
| Rhea expert-curated reactions | 2.4.99.22 |
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