A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.99.6

Accepted Name
N-acetyllactosaminide alpha-2,3-sialyltransferase.
Alternative Name(s)
Neolactotetraosylceramide alpha-2,3-sialyltransferase.
Reaction catalysed
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R <=> CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R
Comment(s)
  • The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
  • The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1.
  • Formerly EC 2.4.99.10.
Cross-references
BRENDA2.4.99.6
EC2PDB2.4.99.6
ExplorEnz2.4.99.6
PRIAM enzyme-specific profiles2.4.99.6
KEGG Ligand Database for Enzyme Nomenclature2.4.99.6
IUBMB Enzyme Nomenclature2.4.99.6
IntEnz2.4.99.6
MEDLINEFind literature relating to 2.4.99.6
MetaCyc2.4.99.6
UniProtKB/Swiss-Prot
Q48211, LST_HAEIN;  P72074, LST_NEIGO;  Q9JUV5, LST_NEIMA;  
P72097, LST_NEIMB;  Q91Y74, SIA4C_MOUSE;  Q11203, SIAT6_HUMAN;  
P97325, SIAT6_MOUSE;  P61132, SIAT6_PANTR;  Q02734, SIAT6_RAT;  

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