A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.4.99.6
| Accepted Name |
|---|
| N-acetyllactosaminide alpha-2,3-sialyltransferase.
|
| Alternative Name(s) |
|---|
| Neolactotetraosylceramide alpha-2,3-sialyltransferase. |
| Reaction catalysed |
|---|
| CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R <=> CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R |
| Comment(s) |
|---|
- The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl-
D-glucosaminyl (known as type 2 histo-blood group precursor
disaccharide) in non-reducing termini of glycan moieties in
glycoproteins and glycolipids.
- The enzyme from chicken brain was shown to act on
neolactotetraosylceramide, producing ganglioside LM1.
- Formerly EC 2.4.99.10.
|
| Cross-references |
|---|
| BRENDA | 2.4.99.6 |
| EC2PDB | 2.4.99.6 |
| ExplorEnz | 2.4.99.6 |
| PRIAM enzyme-specific profiles | 2.4.99.6 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.99.6 |
| IUBMB Enzyme Nomenclature | 2.4.99.6 |
| IntEnz | 2.4.99.6 |
| MEDLINE | Find literature relating to 2.4.99.6 |
| MetaCyc | 2.4.99.6 |
| UniProtKB/Swiss-Prot |
|
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