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ENZYME entry: EC

Accepted Name
N-acetyllactosaminide alpha-2,3-sialyltransferase.
Alternative Name(s)
neolactotetraosylceramide alpha-2,3-sialyltransferase.
Reaction catalysed
a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)
  • The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
  • The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1.
  • Formerly EC
PRIAM enzyme-specific profiles2.4.99.6
KEGG Ligand Database for Enzyme Nomenclature2.4.99.6
IUBMB Enzyme Nomenclature2.4.99.6
MEDLINEFind literature relating to
Rhea expert-curated reactions2.4.99.6
Q48211, LST_HAEIN;  P72074, LST_NEIGO;  Q9JUV5, LST_NEIMA;  
P72097, LST_NEIMB;  Q11206, SIA4C_HUMAN;  Q91Y74, SIA4C_MOUSE;  
P61130, SIA4C_PANTR;  P61131, SIA4C_RAT;  Q11203, SIAT6_HUMAN;  
P97325, SIAT6_MOUSE;  P61132, SIAT6_PANTR;  Q02734, SIAT6_RAT;  

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