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ENZYME entry: EC 2.4.99.6
| Accepted Name |
|---|
| N-acetyllactosaminide alpha-2,3-sialyltransferase.
|
| Alternative Name(s) |
|---|
| neolactotetraosylceramide alpha-2,3-sialyltransferase. |
| Reaction catalysed |
|---|
| a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+) |
| Comment(s) |
|---|
- The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl-
D-glucosaminyl (known as type 2 histo-blood group precursor
disaccharide) in non-reducing termini of glycan moieties in
glycoproteins and glycolipids.
- The enzyme from chicken brain was shown to act on
neolactotetraosylceramide, producing ganglioside LM1.
- Formerly EC 2.4.99.10.
|
| Cross-references |
|---|
| BRENDA | 2.4.99.6 |
| EC2PDB | 2.4.99.6 |
| ExplorEnz | 2.4.99.6 |
| PRIAM enzyme-specific profiles | 2.4.99.6 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.99.6 |
| IUBMB Enzyme Nomenclature | 2.4.99.6 |
| IntEnz | 2.4.99.6 |
| MEDLINE | Find literature relating to 2.4.99.6 |
| MetaCyc | 2.4.99.6 |
| Rhea expert-curated reactions | 2.4.99.6 |
| UniProtKB/Swiss-Prot |
| Q48211, LST_HAEIN; | P72074, LST_NEIGO; | Q9JUV5, LST_NEIMA; |
| P72097, LST_NEIMB; | Q11206, SIA4C_HUMAN; | Q91Y74, SIA4C_MOUSE; |
| P61130, SIA4C_PANTR; | P61131, SIA4C_RAT; | Q11203, SIAT6_HUMAN; |
| P97325, SIAT6_MOUSE; | P61132, SIAT6_PANTR; | Q02734, SIAT6_RAT; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.99.-
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