ENZYME entry: EC 2.4.99.6

Accepted Name

N-acetyllactosaminide alpha-2,3-sialyltransferase.

Alternative Name(s)

Neolactotetraosylceramide alpha-2,3-sialyltransferase.

Reaction catalysed

CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R <=> CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R

Comment(s)

The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1.
Formerly EC 2.4.99.10.

Cross-references

BRENDA

2.4.99.6

EC2PDB

2.4.99.6

ExplorEnz

2.4.99.6

PRIAM enzyme-specific profiles

2.4.99.6

KEGG Ligand Database for Enzyme Nomenclature

2.4.99.6

IUBMB Enzyme Nomenclature

2.4.99.6

IntEnz

2.4.99.6

MEDLINE

Find literature relating to 2.4.99.6

MetaCyc

2.4.99.6

UniProtKB/Swiss-Prot

Q48211, LST_HAEIN;	P72074, LST_NEIGO;	Q9JUV5, LST_NEIMA;
P72097, LST_NEIMB;	Q91Y74, SIA4C_MOUSE;	Q11203, SIAT6_HUMAN;
P97325, SIAT6_MOUSE;	P61132, SIAT6_PANTR;	Q02734, SIAT6_RAT;

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