A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.99.8

Accepted Name
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase.
Alternative Name(s)
Alpha-2,8-sialyltransferase.
Reaction catalysed
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R <=> CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Comment(s)
Gangliosides act as acceptors.
Cross-references
BRENDA2.4.99.8
EC2PDB2.4.99.8
ExplorEnz2.4.99.8
PRIAM enzyme-specific profiles2.4.99.8
KEGG Ligand Database for Enzyme Nomenclature2.4.99.8
IUBMB Enzyme Nomenclature2.4.99.8
IntEnz2.4.99.8
MEDLINEFind literature relating to 2.4.99.8
MetaCyc2.4.99.8
UniProtKB/Swiss-Prot
Q6ZXD2, SIA8A_BOVIN;  Q92185, SIA8A_HUMAN;  Q64687, SIA8A_MOUSE;  
P61642, SIA8A_PANTR;  Q6ZXA0, SIA8A_XENLA;  Q6DNG6, SIA8A_XENTR;  

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