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ENZYME

ENZYME entry: EC 2.5.1.104

Accepted Name
N(1)-aminopropylagmatine synthase
Alternative Name(s)
ACAPT
agmatine/cadaverine aminopropyl transferase
agmatine aminopropyltransferase
triamine/agmatine aminopropyltransferase
Reaction catalysed
agmatine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine
Comment(s)
  • The enzyme is involved in the biosynthesis of spermidine from agmatine in some archaea and bacteria.
  • The enzyme from the Gram-negative bacterium Thermus thermophilus accepts agmatine, spermidine and norspermidine with similar catalytic efficiency.
  • The enzymes from the archaea Pyrococcus furiosus and Thermococcus kodakarensis prefer agmatine, but can utilize cadaverine, putrescine and propane-1,3-diamine with much lower catalytic efficiency. cf. EC 2.5.1.16 and EC 2.5.1.23.
Cross-references
BRENDA2.5.1.104
EC2PDB2.5.1.104
ExplorEnz2.5.1.104
PRIAM enzyme-specific profiles2.5.1.104
KEGG Ligand Database for Enzyme Nomenclature2.5.1.104
IUBMB Enzyme Nomenclature2.5.1.104
IntEnz2.5.1.104
MEDLINEFind literature relating to 2.5.1.104
MetaCyc2.5.1.104
Rhea expert-curated reactions2.5.1.104
UniProtKB/Swiss-Prot
Q8U4G1, SPEE_PYRFUQ5JFG9, SPEE_THEKOQ5SK28, SPEE_THET8

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