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ENZYME

ENZYME entry: EC 2.5.1.128

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.128
Accepted Name
N(4)-bis(aminopropyl)spermidine synthase
Reaction catalysed
2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine + 2 H(+)
Comment(s)
  • The enzyme, characterized from the thermophilic archaeon Thermococcus kodakarensis, synthesizes the branched-chain polyamine N(4)- bis(aminopropyl)spermidine, which is required for cell growth at high-temperature.
  • When spermine is used as substrate, the enzyme forms N(4)- aminopropylspermine.
Cross-references
BRENDA2.5.1.128
EC2PDB2.5.1.128
ExplorEnz2.5.1.128
KEGG Ligand Database for Enzyme Nomenclature2.5.1.128
IUBMB Enzyme Nomenclature2.5.1.128
MEDLINEFind literature relating to 2.5.1.128
MetaCyc2.5.1.128
Rhea expert-curated reactions2.5.1.128
UniProtKB/Swiss-Prot
Q58669, BPSA_METJAQ5JIZ3, BPSA_THEKOP25125, BPSA_THETH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-