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ENZYME entry: EC 2.5.1.136

Accepted Name
2-acylphloroglucinol 4-prenyltransferase.
Alternative Name(s)
Aromatic prenyltransferase.
Reaction catalysed
Prenyl diphosphate + a 2-acylphloroglucinol <=> diphosphate + a 2-acyl-4-prenylphloroglucinol
Cofactor(s)
Mg(2+).
Comment(s)
  • The enzyme, characterized from hop (Humulus lupulus), acts on phlorisovalerophenone, phlormethylbutanophenone, and phlorisobutanophenone during the synthesis of bitter acids.
  • It also acts with much lower activity on naringenin chalcone.
  • Forms a complex with EC 2.5.1.137 which catalyzes additional prenylation reactions.
Cross-references
BRENDA2.5.1.136
EC2PDB2.5.1.136
ExplorEnz2.5.1.136
PRIAM enzyme-specific profiles2.5.1.136
KEGG Ligand Database for Enzyme Nomenclature2.5.1.136
IUBMB Enzyme Nomenclature2.5.1.136
IntEnz2.5.1.136
MEDLINEFind literature relating to 2.5.1.136
MetaCyc2.5.1.136
Rhea expert-curated reactions2.5.1.136
UniProtKB/Swiss-Prot
A0A0B5A051, PT1L_HUMLU;  E5RP65, PT1_HUMLU;  

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