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ENZYME entry: EC 2.5.1.137

Accepted Name
2-acyl-4-prenylphloroglucinol 6-prenyltransferase.
Alternative Name(s)
Aromatic prenyltransferase.
Reaction catalysed
  • Dimethylallyl diphosphate + a 2-acyl-4-prenylphloroglucinol <=> diphosphate + a 2-acyl-4,6-bisprenylphloroglucinol
  • Dimethylallyl diphosphate + a 2-acyl-4,6-bisprenylphloroglucinol <=> diphosphate + a 2-acyl-4,6,6-trisprenylphloroglucinol
Cofactor(s)
Mg(2+).
Comment(s)
  • The enzyme, characterized from hop (Humulus lupulus), catalyzes two successive prenylations of a 2-acyl-4-prenylphloroglucinol during the synthesis of bitter acids.
  • Forms a complex with EC 2.5.1.136 which catalyzes the initial prenylation of the substrates.
Cross-references
BRENDA2.5.1.137
EC2PDB2.5.1.137
ExplorEnz2.5.1.137
PRIAM enzyme-specific profiles2.5.1.137
KEGG Ligand Database for Enzyme Nomenclature2.5.1.137
IUBMB Enzyme Nomenclature2.5.1.137
IntEnz2.5.1.137
MEDLINEFind literature relating to 2.5.1.137
MetaCyc2.5.1.137
UniProtKB/Swiss-Prot
A0A0B4ZTQ2, PT2_HUMLU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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