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ENZYME

ENZYME entry: EC 2.5.1.147

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.147
Accepted Name
5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase
Reaction catalysed
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + 5'-deoxyadenosine + L-methionine + H(+)
Comment(s)
  • The enzyme is involved in the production of 7,8-didemethyl-8-hydroxy- 5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420, which is found in methanogens and in various actinobacteria.
  • FO is also produced by some cyanobacteria and eukaryotes.
  • The enzyme, which forms a complex with EC 4.3.1.32 is a radical SAM enzyme that uses the 5'-deoxyadenosyl radical to initiate the reaction.
  • Formerly EC 2.5.1.77.
Cross-references
BRENDA2.5.1.147
EC2PDB2.5.1.147
ExplorEnz2.5.1.147
KEGG Ligand Database for Enzyme Nomenclature2.5.1.147
IUBMB Enzyme Nomenclature2.5.1.147
MEDLINEFind literature relating to 2.5.1.147
MetaCyc2.5.1.147
Rhea expert-curated reactions2.5.1.147
UniProtKB/Swiss-Prot
Q8TQQ0, COFH1_METACQ466A3, COFH1_METBFQ8PU54, COFH1_METMA
Q6M161, COFH1_METMPQ8TQQ1, COFH2_METACQ466A2, COFH2_METBF
Q8PU53, COFH2_METMAQ6M160, COFH2_METMPO29460, COFH_ARCFU
B8HP19, COFH_CYAP4Q7NMI9, COFH_GLOVIQ5UXN1, COFH_HALMA
Q9HNU8, COFH_HALSAA6UV11, COFH_META3Q0W6V4, COFH_METAR
Q12WF5, COFH_METBUQ2FSC7, COFH_METHJQ58826, COFH_METJA
Q8TWY4, COFH_METKAA4G0D4, COFH_METM5A9A8N5, COFH_METM6
A6VI43, COFH_METM7A3CRI3, COFH_METMJB8GI94, COFH_METPE
O26911, COFH_METTHA6UR49, COFH_METVSB0JTF9, COFH_MICAN
B2IW30, COFH_NOSP7Q8YPR3, COFH_NOSS1Q31QF1, COFH_SYNE7
Q5N3T7, COFH_SYNP6P72811, COFH_SYNY3Q8DII8, COFH_THEVB
Q113H3, COFH_TRIEIQ3MF37, COFH_TRIV2Q7U0G9, FBIC_MYCBO
Q9CBX6, FBIC_MYCLEQ73WP9, FBIC_MYCPAP9WP76, FBIC_MYCTO
P9WP77, FBIC_MYCTUQ5YQD7, FBIC_NOCFAQ82GV2, FBIC_STRAW
Q9KZZ7, FBIC_STRCO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-