Home  |  Contact

ENZYME entry: EC 4.3.1.32

Accepted Name
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase.
Alternative Name(s)
F(0)-synthase.
FO synthase.
Reaction catalysed
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine <=> 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH(3) + L-methionine + 5'-deoxyadenosine
Comment(s)
  • The enzyme produces the F(0) precursor of the redox cofactor coenzyme F420, which is found in methanogens and in various actinobacteria.
  • F(0) is also produced by some cyanobacteria and eukaryotes.
  • The enzyme, which forms a complex with EC 2.5.1.147, is a radical SAM enzyme that uses the 5'-deoxyadenosyl radical to catalyze the condensation reaction.
  • Formerly EC 2.5.1.77.
Cross-references
BRENDA4.3.1.32
EC2PDB4.3.1.32
ExplorEnz4.3.1.32
PRIAM enzyme-specific profiles4.3.1.32
KEGG Ligand Database for Enzyme Nomenclature4.3.1.32
IUBMB Enzyme Nomenclature4.3.1.32
IntEnz4.3.1.32
MEDLINEFind literature relating to 4.3.1.32
MetaCyc4.3.1.32
UniProtKB/Swiss-Prot
O29461, COFG_ARCFU;  Q7NIT2, COFG_GLOVI;  Q5UXN0, COFG_HALMA;  
B0R6P8, COFG_HALS3;  Q9HNU9, COFG_HALSA;  A6UVH0, COFG_META3;  
Q8TQP9, COFG_METAC;  A7IAF4, COFG_METB6;  Q466A4, COFG_METBF;  
Q12WF6, COFG_METBU;  Q57888, COFG_METJA;  Q8TWY3, COFG_METKA;  
A4FXR1, COFG_METM5;  A9AB67, COFG_METM6;  A6VFG8, COFG_METM7;  
Q8PU55, COFG_METMA;  A3CWL4, COFG_METMJ;  Q6LYV9, COFG_METMP;  
B8GGS3, COFG_METPE;  A5UM12, COFG_METS3;  O27266, COFG_METTH;  
A0B5P5, COFG_METTP;  A6UN87, COFG_METVS;  Q8YR77, COFG_NOSS1;  
Q31PU7, COFG_SYNE7;  Q5N4D1, COFG_SYNP6;  P73191, COFG_SYNY3;  
Q8DIR6, COFG_THEEB;  Q11A09, COFG_TRIEI;  Q3MCR5, COFG_TRIV2;  
Q7U0G9, FBIC_MYCBO;  Q9CBX6, FBIC_MYCLE;  Q73WP9, FBIC_MYCPA;  
P9WP76, FBIC_MYCTO;  P9WP77, FBIC_MYCTU;  Q5YQD7, FBIC_NOCFA;  
Q82GV2, FBIC_STRAW;  Q9KZZ7, FBIC_STRCO;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-