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ENZYME entry: EC 2.5.1.149

Accepted Name
Lycopene elongase/hydratase (flavuxanthin-forming).
Reaction catalysed
  • Dimethylallyl diphosphate + all-trans-lycopene + acceptor + H(2)O <=> nonaflavuxanthin + reduced electron acceptor + diphosphate
  • Dimethylallyl diphosphate + nonaflavuxanthin + acceptor + H(2)O <=> flavuxanthin + reduced electron acceptor + diphosphate
Comment(s)
  • The enzyme, characterized from the bacterium Corynebacterium glutamicum, is bifunctional.
  • It catalyzes the elongation of the C(40) carotenoid all-trans- lycopene by attaching an isoprene unit at C-2, as well as the hydroxylation of the new isoprene unit.
  • The enzyme acts at both ends of the substrate, forming the C(50) carotenoid flavuxanthin via the C(45) intermediate nonaflavuxanthin.
  • Cf. EC 2.5.1.150.
Cross-references
BRENDA2.5.1.149
EC2PDB2.5.1.149
ExplorEnz2.5.1.149
PRIAM enzyme-specific profiles2.5.1.149
KEGG Ligand Database for Enzyme Nomenclature2.5.1.149
IUBMB Enzyme Nomenclature2.5.1.149
IntEnz2.5.1.149
MEDLINEFind literature relating to 2.5.1.149
MetaCyc2.5.1.149
Rhea expert-curated reactions2.5.1.149
UniProtKB/Swiss-Prot
Q8NSP8, CRTEB_CORGL;  Q93QX2, CRTEB_CORGT;  

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