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ENZYME entry: EC 2.5.1.150

Accepted Name
Lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming).
Reaction catalysed
  • Dimethylallyl diphosphate + all-trans-lycopene + H(2)O <=> dihydroisopentenyldehydrorhodopin + diphosphate
  • Dimethylallyl diphosphate + isopentenyldehydrorhodopin + H(2)O <=> dihydrobisanhydrobacterioruberin + diphosphate
Comment(s)
  • The enzyme, characterized from the bacterium Dietzia sp. CQ4 and the halophilic archaea Halobacterium salinarum and Haloarcula japonica, is bifunctional.
  • It catalyzes the elongation of the C(40) carotenoid all-trans- lycopene by attaching an isoprene unit at C-2 as well as the hydroxylation of the previous end of the molecule.
  • The enzyme acts at both ends of the substrate, and combined with the action of EC 1.3.99.37, it forms the C(50) carotenoid dihydrobisanhydrobacterioruberin.
  • Cf. EC 2.5.1.149.
Cross-references
BRENDA2.5.1.150
EC2PDB2.5.1.150
ExplorEnz2.5.1.150
PRIAM enzyme-specific profiles2.5.1.150
KEGG Ligand Database for Enzyme Nomenclature2.5.1.150
IUBMB Enzyme Nomenclature2.5.1.150
IntEnz2.5.1.150
MEDLINEFind literature relating to 2.5.1.150
MetaCyc2.5.1.150
Rhea expert-curated reactions2.5.1.150
UniProtKB/Swiss-Prot
A1XI30, LBTBC_DIESC;  M0L7V9, LYEL_HALJT;  Q9HPD9, LYEL_HALSA;  
D4GTV9, LYEL_HALVD;  

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