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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Homospermidine synthase.
Reaction catalysed
  • 2 putrescine <=> sym-homospermidine + NH(3) + H(+)
  • Putrescine + spermidine <=> sym-homospermidine + propane-1,3-diamine
  • The reaction of this enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: NAD(+)-dependent dehydrogenation of putrescine, transfer of the 4-aminobutylidene group from dehydroputrescine to a second molecule of putrescine and reduction of the imine intermediate to form homospermidine.
  • Hence the overall reaction is transfer of a 4-aminobutyl group.
  • Differs from EC, which cannot use putrescine as donor of the aminobutyl group.
PRIAM enzyme-specific profiles2.5.1.44
KEGG Ligand Database for Enzyme Nomenclature2.5.1.44
IUBMB Enzyme Nomenclature2.5.1.44
MEDLINEFind literature relating to
O32323, HSS_BLAVI;  Q98H64, HSS_RHILO;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-