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ENZYME entry: EC 2.5.1.44

Accepted Name
homospermidine synthase.
Reaction catalysed
  • 2 putrescine <=> NH4(+) + sym-homospermidine
  • putrescine + spermidine <=> propane-1,3-diamine + sym-homospermidine
Comment(s)
  • The reaction of this bacterial enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: (1) NAD(+)-dependent dehydrogenation of either putrescine or spermidine. (2) Attack by water forming 4-aminobutanal (and releasing ammonia or propane-1,3-diamine, respectively). (3) Condensation of 4-aminobutanal with putrescine, which forms homospermidine and restores NAD(+).
  • Differs from the eukaryotic enzyme EC 2.5.1.45, which cannot use putrescine as donor of the aminobutyl group.
Cross-references
BRENDA2.5.1.44
EC2PDB2.5.1.44
ExplorEnz2.5.1.44
PRIAM enzyme-specific profiles2.5.1.44
KEGG Ligand Database for Enzyme Nomenclature2.5.1.44
IUBMB Enzyme Nomenclature2.5.1.44
IntEnz2.5.1.44
MEDLINEFind literature relating to 2.5.1.44
MetaCyc2.5.1.44
Rhea expert-curated reactions2.5.1.44
UniProtKB/Swiss-Prot
O32323, HSS_BLAVI;  Q98H64, HSS_RHILO;  

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