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ENZYME entry: EC 2.5.1.45

Accepted Name
Homospermidine synthase (spermidine-specific).
Reaction catalysed
Spermidine + putrescine <=> sym-homospermidine + propane-1,3-diamine
Cofactor(s)
NAD(+).
Comment(s)
  • The reaction of this enzyme occurs in three steps: (1) NAD(+)-dependent dehydrogenation of spermidine. (2) Transfer of the 4-aminobutylidene group from dehydrospermidine to a second molecule of putrescine. (3) Reduction of the imine intermediate to form homospermidine.
  • Hence the overall reaction is transfer of a 4-aminobutyl group.
  • This enzyme is more specific than EC 2.5.1.44 which is found in bacteria, as it cannot use putrescine as donor of the 4-aminobutyl group.
  • Forms part of the biosynthetic pathway of the poisonous pyrrolizidine alkaloids of the ragworts (Senecio).
Cross-references
BRENDA2.5.1.45
EC2PDB2.5.1.45
ExplorEnz2.5.1.45
PRIAM enzyme-specific profiles2.5.1.45
KEGG Ligand Database for Enzyme Nomenclature2.5.1.45
IUBMB Enzyme Nomenclature2.5.1.45
IntEnz2.5.1.45
MEDLINEFind literature relating to 2.5.1.45
MetaCyc2.5.1.45
UniProtKB/Swiss-Prot
Q9SC13, HSS1_SENVE;  Q9M4B0, HSS1_SENVU;  P60038, HSS2_SENVE;  

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