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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Homospermidine synthase (spermidine-specific).
Reaction catalysed
Spermidine + putrescine <=> sym-homospermidine + propane-1,3-diamine
  • The reaction of this enzyme occurs in three steps: (1) NAD(+)-dependent dehydrogenation of spermidine. (2) Transfer of the 4-aminobutylidene group from dehydrospermidine to a second molecule of putrescine. (3) Reduction of the imine intermediate to form homospermidine.
  • Hence the overall reaction is transfer of a 4-aminobutyl group.
  • This enzyme is more specific than EC which is found in bacteria, as it cannot use putrescine as donor of the 4-aminobutyl group.
  • Forms part of the biosynthetic pathway of the poisonous pyrrolizidine alkaloids of the ragworts (Senecio).
PRIAM enzyme-specific profiles2.5.1.45
KEGG Ligand Database for Enzyme Nomenclature2.5.1.45
IUBMB Enzyme Nomenclature2.5.1.45
MEDLINEFind literature relating to
Q9SC13, HSS1_SENVE;  Q9M4B0, HSS1_SENVU;  P60038, HSS2_SENVE;  

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