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ENZYME entry: EC 2.5.1.48
Accepted Name |
cystathionine gamma-synthase.
|
Alternative Name(s) |
cystathionine synthase. |
cystathionine synthetase. |
homoserine transsuccinylase. |
O-succinylhomoserine (thiol)-lyase. |
O-succinylhomoserine synthase. |
O-succinylhomoserine synthetase. |
O-succinyl-L-homoserine succinate-lyase (adding cysteine). |
Reaction catalysed |
L-cysteine + O-succinyl-L-homoserine <=> H(+) + L,L-cystathionine + succinate |
Comment(s) |
- Also reacts with H2S and methanethiol as replacing agents, producing
homocysteine and methionine, respectively.
- In the absence of thiol, can also catalyze beta,gamma-elimination to
form 2-oxobutanoate, succinate and ammonia.
- Formerly EC 4.2.99.9.
|
Cross-references |
BRENDA | 2.5.1.48 |
EC2PDB | 2.5.1.48 |
ExplorEnz | 2.5.1.48 |
PRIAM enzyme-specific profiles | 2.5.1.48 |
KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.48 |
IUBMB Enzyme Nomenclature | 2.5.1.48 |
IntEnz | 2.5.1.48 |
MEDLINE | Find literature relating to 2.5.1.48 |
MetaCyc | 2.5.1.48 |
Rhea expert-curated reactions | 2.5.1.48 |
UniProtKB/Swiss-Prot |
P55217, CGS1_ARATH; | Q9C876, CGS2_ARATH; | P38675, MET7_NEUCR; |
O74314, MET7_SCHPO; | P47164, MET7_YEAST; | P00935, METB_ECOLI; |
P44502, METB_HAEIN; | Q9ZMW7, METB_HELPJ; | Q1M0P5, METB_HELPX; |
P56069, METB_HELPY; | P24601, METB_HERAU; | P66876, METB_MYCBO; |
P46807, METB_MYCLE; | P9WGB6, METB_MYCTO; | P9WGB7, METB_MYCTU; |
Q12198, METW_YEAST; | Q04533, METX_YEAST; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
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