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ENZYME entry: EC 2.5.1.48

Accepted Name
Cystathionine gamma-synthase.
Alternative Name(s)
Cystathionine synthase.
Cystathionine synthetase.
Homoserine transsuccinylase.
O-succinyl-L-homoserine succinate-lyase (adding cysteine).
O-succinylhomoserine (thiol)-lyase.
O-succinylhomoserine synthase.
O-succinylhomoserine synthetase.
Reaction catalysed
O(4)-succinyl-L-homoserine + L-cysteine <=> L-cystathionine + succinate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • Also reacts with H(2)S and methanethiol as replacing agents, producing homocysteine and methionine, respectively.
  • In the absence of thiol, can also catalyze beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
  • Formerly EC 4.2.99.9.
Cross-references
PROSITEPDOC00677
BRENDA2.5.1.48
EC2PDB2.5.1.48
ExplorEnz2.5.1.48
PRIAM enzyme-specific profiles2.5.1.48
KEGG Ligand Database for Enzyme Nomenclature2.5.1.48
IUBMB Enzyme Nomenclature2.5.1.48
IntEnz2.5.1.48
MEDLINEFind literature relating to 2.5.1.48
MetaCyc2.5.1.48
Rhea expert-curated reactions2.5.1.48
UniProtKB/Swiss-Prot
P55217, CGS1_ARATH;  Q9C876, CGS2_ARATH;  P38675, MET7_NEUCR;  
O74314, MET7_SCHPO;  P47164, MET7_YEAST;  P00935, METB_ECOLI;  
P44502, METB_HAEIN;  Q9ZMW7, METB_HELPJ;  Q1M0P5, METB_HELPX;  
P56069, METB_HELPY;  P24601, METB_HERAU;  P66876, METB_MYCBO;  
P46807, METB_MYCLE;  P9WGB6, METB_MYCTO;  P9WGB7, METB_MYCTU;  
Q12198, METW_YEAST;  Q04533, METX_YEAST;  

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