| Accepted Name |
|---|
| cystathionine gamma-synthase.
|
| Alternative Name(s) |
|---|
| cystathionine synthase. |
| cystathionine synthetase. |
| homoserine transsuccinylase. |
| O-succinylhomoserine (thiol)-lyase. |
| O-succinylhomoserine synthase. |
| O-succinylhomoserine synthetase. |
| O-succinyl-L-homoserine succinate-lyase (adding cysteine). |
| Reaction catalysed |
|---|
| L-cysteine + O-succinyl-L-homoserine <=> H(+) + L,L-cystathionine + succinate |
| Comment(s) |
|---|
- Also reacts with H2S and methanethiol as replacing agents, producing
homocysteine and methionine, respectively.
- In the absence of thiol, can also catalyze beta,gamma-elimination to
form 2-oxobutanoate, succinate and ammonia.
- Formerly EC 4.2.99.9.
|
| Cross-references |
|---|
| BRENDA | 2.5.1.48 |
| EC2PDB | 2.5.1.48 |
| ExplorEnz | 2.5.1.48 |
| PRIAM enzyme-specific profiles | 2.5.1.48 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.48 |
| IUBMB Enzyme Nomenclature | 2.5.1.48 |
| IntEnz | 2.5.1.48 |
| MEDLINE | Find literature relating to 2.5.1.48 |
| MetaCyc | 2.5.1.48 |
| Rhea expert-curated reactions | 2.5.1.48 |
| UniProtKB/Swiss-Prot |
| P55217, CGS1_ARATH; | Q9C876, CGS2_ARATH; | P38675, MET7_NEUCR; |
| O74314, MET7_SCHPO; | P47164, MET7_YEAST; | P00935, METB_ECOLI; |
| P44502, METB_HAEIN; | Q9ZMW7, METB_HELPJ; | Q1M0P5, METB_HELPX; |
| P56069, METB_HELPY; | P24601, METB_HERAU; | P66876, METB_MYCBO; |
| P46807, METB_MYCLE; | P9WGB6, METB_MYCTO; | P9WGB7, METB_MYCTU; |
| Q12198, METW_YEAST; | Q04533, METX_YEAST; |
|