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ENZYME

ENZYME entry: EC 2.5.1.73

Accepted Name
O-phospho-L-seryl-tRNA:Cys-tRNA synthase
Alternative Name(s)
SepCysS
Sep-tRNA:Cys-tRNA synthase
Reaction catalysed
H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) <=> L-cysteinyl-tRNA(Cys) + phosphate
Comment(s)
  • In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 for the direct Cys-tRNA(Cys) formation, Cys-tRNA(Cys) is produced by an indirect pathway, in which EC 6.1.1.27 ligates O-phosphoserine to tRNA(Cys), and EC 2.5.1.73 converts the produced O-phospho-L-seryl- tRNA(Cys) to Cys-tRNA(Cys).
  • The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism.
  • Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 and the indirect pathway with EC 6.1.1.27 and EC 2.5.1.73.
  • Formerly EC 2.5.1.n3.
Cross-references
BRENDA2.5.1.73
EC2PDB2.5.1.73
ExplorEnz2.5.1.73
PRIAM enzyme-specific profiles2.5.1.73
KEGG Ligand Database for Enzyme Nomenclature2.5.1.73
IUBMB Enzyme Nomenclature2.5.1.73
IntEnz2.5.1.73
MEDLINEFind literature relating to 2.5.1.73
MetaCyc2.5.1.73
Rhea expert-curated reactions2.5.1.73
UniProtKB/Swiss-Prot
O30207, SPSS1_ARCFUQ0W2L3, SPSS1_METARA7I757, SPSS1_METB6
Q12XS4, SPSS1_METBUQ2FLN5, SPSS1_METHJA2SQB8, SPSS1_METLZ
O30056, SPSS2_ARCFUQ0W486, SPSS2_METARA7I9Z8, SPSS2_METB6
Q12W26, SPSS2_METBUQ2FTY4, SPSS2_METHJA2SSS7, SPSS2_METLZ
A6UUU3, SPSS_META3Q8TSS3, SPSS_METACQ46C09, SPSS_METBF
Q59072, SPSS_METJAQ8TYR3, SPSS_METKAA4FWT8, SPSS_METM5
A9AA73, SPSS_METM6A6VGH9, SPSS_METM7Q8PVS9, SPSS_METMA
A3CVZ3, SPSS_METMJQ6LXV6, SPSS_METMPO27139, SPSS_METTH
A0B5D0, SPSS_METTPA6UPN9, SPSS_METVS

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
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