A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.5.1.73
| Accepted Name |
|---|
| O-phospho-L-seryl-tRNA:Cys-tRNA synthase.
|
| Alternative Name(s) |
|---|
| Sep-tRNA:Cys-tRNA synthase. |
| SepCysS. |
| Reaction catalysed |
|---|
| O-phospho-L-seryl-tRNA(Cys) + sulfide <=> L-cysteinyl-tRNA(Cys) + phosphate |
| Comment(s) |
|---|
- In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 for the
direct Cys-tRNA(Cys) formation, Cys-tRNA(Cys) is produced by an
indirect pathway, in which EC 6.1.1.27 ligates O-phosphoserine to
tRNA(Cys), and EC 2.5.1.73 converts the produced O-phospho-L-seryl-
tRNA(Cys) to Cys-tRNA(Cys).
- The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis
in the organism.
- Methanosarcina mazei can use both pathways, the direct route using
EC 6.1.1.16 and the indirect pathway with EC 6.1.1.27 and
EC 2.5.1.73.
- Formerly EC 2.5.1.n3.
|
| Cross-references |
|---|
| BRENDA | 2.5.1.73 |
| EC2PDB | 2.5.1.73 |
| ExplorEnz | 2.5.1.73 |
| PRIAM enzyme-specific profiles | 2.5.1.73 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.73 |
| IUBMB Enzyme Nomenclature | 2.5.1.73 |
| IntEnz | 2.5.1.73 |
| MEDLINE | Find literature relating to 2.5.1.73 |
| MetaCyc | 2.5.1.73 |
| UniProtKB/Swiss-Prot |
| O30207, SPSS1_ARCFU; | Q0W2L3, SPSS1_METAR; | A7I757, SPSS1_METB6; |
| Q12XS4, SPSS1_METBU; | Q2FLN5, SPSS1_METHJ; | A2SQB8, SPSS1_METLZ; |
| O30056, SPSS2_ARCFU; | Q0W486, SPSS2_METAR; | A7I9Z8, SPSS2_METB6; |
| Q12W26, SPSS2_METBU; | Q2FTY4, SPSS2_METHJ; | A2SSS7, SPSS2_METLZ; |
| A6UUU3, SPSS_META3; | Q8TSS3, SPSS_METAC; | Q46C09, SPSS_METBF; |
| Q59072, SPSS_METJA; | Q8TYR3, SPSS_METKA; | A4FWT8, SPSS_METM5; |
| A9AA73, SPSS_METM6; | A6VGH9, SPSS_METM7; | Q8PVS9, SPSS_METMA; |
| A3CVZ3, SPSS_METMJ; | Q6LXV6, SPSS_METMP; | O27139, SPSS_METTH; |
| A0B5D0, SPSS_METTP; | A6UPN9, SPSS_METVS; |
|
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