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ENZYME entry: EC 2.5.1.73

Accepted Name
O-phospho-L-seryl-tRNA:Cys-tRNA synthase.
Alternative Name(s)
Sep-tRNA:Cys-tRNA synthase.
SepCysS.
Reaction catalysed
O-phospho-L-seryl-tRNA(Cys) + sulfide <=> L-cysteinyl-tRNA(Cys) + phosphate
Comment(s)
  • In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 for the direct Cys-tRNA(Cys) formation, Cys-tRNA(Cys) is produced by an indirect pathway, in which EC 6.1.1.27 ligates O-phosphoserine to tRNA(Cys), and EC 2.5.1.73 converts the produced O-phospho-L-seryl- tRNA(Cys) to Cys-tRNA(Cys).
  • The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism.
  • Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 and the indirect pathway with EC 6.1.1.27 and EC 2.5.1.73.
  • Formerly EC 2.5.1.n3.
Cross-references
BRENDA2.5.1.73
EC2PDB2.5.1.73
ExplorEnz2.5.1.73
PRIAM enzyme-specific profiles2.5.1.73
KEGG Ligand Database for Enzyme Nomenclature2.5.1.73
IUBMB Enzyme Nomenclature2.5.1.73
IntEnz2.5.1.73
MEDLINEFind literature relating to 2.5.1.73
MetaCyc2.5.1.73
Rhea expert-curated reactions2.5.1.73
UniProtKB/Swiss-Prot
O30207, SPSS1_ARCFU;  Q0W2L3, SPSS1_METAR;  A7I757, SPSS1_METB6;  
Q12XS4, SPSS1_METBU;  Q2FLN5, SPSS1_METHJ;  A2SQB8, SPSS1_METLZ;  
O30056, SPSS2_ARCFU;  Q0W486, SPSS2_METAR;  A7I9Z8, SPSS2_METB6;  
Q12W26, SPSS2_METBU;  Q2FTY4, SPSS2_METHJ;  A2SSS7, SPSS2_METLZ;  
A6UUU3, SPSS_META3;  Q8TSS3, SPSS_METAC;  Q46C09, SPSS_METBF;  
Q59072, SPSS_METJA;  Q8TYR3, SPSS_METKA;  A4FWT8, SPSS_METM5;  
A9AA73, SPSS_METM6;  A6VGH9, SPSS_METM7;  Q8PVS9, SPSS_METMA;  
A3CVZ3, SPSS_METMJ;  Q6LXV6, SPSS_METMP;  O27139, SPSS_METTH;  
A0B5D0, SPSS_METTP;  A6UPN9, SPSS_METVS;  

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