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ENZYME

ENZYME entry: EC 2.6.1.123

PURL: https://purl.expasy.org/enzyme/EC/2.6.1.123
Accepted Name
4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming)
Alternative Name(s)
ADCS
ADC synthase
Reaction catalysed
chorismate + 2 L-glutamine + H2O = 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)
Comment(s)
  • The enzyme, characterized from the bacterium Bacillus subtilis, is a heterodimer.
  • The PabA subunit acts successively on two molecules of L-glutamine, hydrolyzing each to L-glutamate and ammonia (cf. EC 3.5.1.2, glutaminase).
  • The ammonia molecules are channeled to the active site of PabB, which catalyzes the formation of 4-amino-4-deoxychorismate from chorismate in two steps, via the intermediate 2-amino-4-deoxychorismate. cf. EC 2.6.1.85.
Cross-references
BRENDA2.6.1.123
EC2PDB2.6.1.123
ExplorEnz2.6.1.123
KEGG Ligand Database for Enzyme Nomenclature2.6.1.123
IUBMB Enzyme Nomenclature2.6.1.123
MEDLINEFind literature relating to 2.6.1.123
MetaCyc2.6.1.123
Rhea expert-curated reactions2.6.1.123

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-