ENZYME entry: EC 2.6.1.85
Accepted Name |
aminodeoxychorismate synthase.
|
Alternative Name(s) |
4-amino-4-deoxychorismate synthase. |
ADC synthase. |
Reaction catalysed |
chorismate + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate |
Comment(s) |
- The enzyme is composed of two parts, a glutaminase (PabA in
Escherichia coli) and an aminotransferase (PabB).
- In the absence of PabA and glutamine (but in the presence of Mg(2+)),
PabB can convert ammonia and chorismate into 4-amino-4-
deoxychorismate.
- PabA converts glutamine into glutamate only in the presence of
stoichiometric amounts of PabB.
- In many organisms, including plants, the genes encoding the two
proteins have fused to encode a single bifunctional protein. This
enzyme is coupled with EC 4.1.3.38 to form 4-aminobenzoate. cf.
EC 2.6.1.123.
- Formerly EC 6.3.5.8.
|
Cross-references |
BRENDA | 2.6.1.85 |
EC2PDB | 2.6.1.85 |
ExplorEnz | 2.6.1.85 |
PRIAM enzyme-specific profiles | 2.6.1.85 |
KEGG Ligand Database for Enzyme Nomenclature | 2.6.1.85 |
IUBMB Enzyme Nomenclature | 2.6.1.85 |
IntEnz | 2.6.1.85 |
MEDLINE | Find literature relating to 2.6.1.85 |
MetaCyc | 2.6.1.85 |
Rhea expert-curated reactions | 2.6.1.85 |
UniProtKB/Swiss-Prot |
Q8LPN3, ADCS_ARATH; | Q5Z856, ADCS_ORYSJ; | O94277, ADCS_SCHPO; |
Q6TAS3, ADCS_SOLLC; | P32483, ADCS_STRGR; | P72539, ADCS_STRPR; |
F2RB79, ADCS_STRVP; | P37254, ADCS_YEAST; | P28819, PABA_BACSU; |
P00903, PABA_ECOLI; | P06194, PABA_KLEAE; | P06193, PABA_SALTY; |
P06195, PABA_SERMA; | P27627, PABA_STRLI; | P28820, PABB_BACSU; |
P05041, PABB_ECOLI; | P12679, PABB_KLEAE; | P27629, PABB_LACLL; |
P12680, PABB_SALTY; | P27630, PABB_STRLI; |
|
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UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
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