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ENZYME

ENZYME entry: EC 2.6.1.85

PURL: https://purl.expasy.org/enzyme/EC/2.6.1.85
Accepted Name
aminodeoxychorismate synthase
Alternative Name(s)
4-amino-4-deoxychorismate synthase
ADC synthase
Reaction catalysed
chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
Comment(s)
  • The enzyme is composed of two parts, a glutaminase (PabA in Escherichia coli) and an aminotransferase (PabB).
  • In the absence of PabA and glutamine (but in the presence of Mg(2+)), PabB can convert ammonia and chorismate into 4-amino-4- deoxychorismate.
  • PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB.
  • In many organisms, including plants, the genes encoding the two proteins have fused to encode a single bifunctional protein. This enzyme is coupled with EC 4.1.3.38 to form 4-aminobenzoate. cf. EC 2.6.1.123.
  • Formerly EC 6.3.5.8.
Cross-references
BRENDA2.6.1.85
EC2PDB2.6.1.85
ExplorEnz2.6.1.85
KEGG Ligand Database for Enzyme Nomenclature2.6.1.85
IUBMB Enzyme Nomenclature2.6.1.85
MEDLINEFind literature relating to 2.6.1.85
MetaCyc2.6.1.85
Rhea expert-curated reactions2.6.1.85
UniProtKB/Swiss-Prot
Q8LPN3, ADCS_ARATHQ5Z856, ADCS_ORYSJO94277, ADCS_SCHPO
Q6TAS3, ADCS_SOLLCP32483, ADCS_STRGRP72539, ADCS_STRPR
F2RB79, ADCS_STRVPP37254, ADCS_YEASTP28819, PABA_BACSU
P00903, PABA_ECOLIP06194, PABA_KLEAEP06193, PABA_SALTY
P06195, PABA_SERMAP27627, PABA_STRLIP28820, PABB_BACSU
P05041, PABB_ECOLIP12679, PABB_KLEAEP27629, PABB_LACLL
P12680, PABB_SALTYP27630, PABB_STRLI

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