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ENZYME entry: EC 2.6.1.85

Accepted Name
aminodeoxychorismate synthase.
Alternative Name(s)
4-amino-4-deoxychorismate synthase.
ADC synthase.
Reaction catalysed
chorismate + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate
Comment(s)
  • The enzyme is composed of two parts, a glutaminase (PabA in Escherichia coli) and an aminotransferase (PabB).
  • In the absence of PabA and glutamine (but in the presence of Mg(2+)), PabB can convert ammonia and chorismate into 4-amino-4- deoxychorismate.
  • PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB.
  • In many organisms, including plants, the genes encoding the two proteins have fused to encode a single bifunctional protein.
  • This enzyme is coupled with EC 4.1.3.38 to form 4-aminobenzoate.
  • cf. EC 2.6.1.123.
  • Formerly EC 6.3.5.8.
Cross-references
BRENDA2.6.1.85
EC2PDB2.6.1.85
ExplorEnz2.6.1.85
PRIAM enzyme-specific profiles2.6.1.85
KEGG Ligand Database for Enzyme Nomenclature2.6.1.85
IUBMB Enzyme Nomenclature2.6.1.85
IntEnz2.6.1.85
MEDLINEFind literature relating to 2.6.1.85
MetaCyc2.6.1.85
Rhea expert-curated reactions2.6.1.85
UniProtKB/Swiss-Prot
Q8LPN3, ADCS_ARATH;  Q5Z856, ADCS_ORYSJ;  O94277, ADCS_SCHPO;  
Q6TAS3, ADCS_SOLLC;  P32483, ADCS_STRGR;  P72539, ADCS_STRPR;  
F2RB79, ADCS_STRVP;  P37254, ADCS_YEAST;  P28819, PABA_BACSU;  
P00903, PABA_ECOLI;  P06194, PABA_KLEAE;  P06193, PABA_SALTY;  
P06195, PABA_SERMA;  P27627, PABA_STRLI;  P28820, PABB_BACSU;  
P05041, PABB_ECOLI;  P12679, PABB_KLEAE;  P27629, PABB_LACLL;  
P12680, PABB_SALTY;  P27630, PABB_STRLI;  

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