ENZYME entry: EC 2.6.1.86
Accepted Name |
2-amino-4-deoxychorismate synthase.
|
Alternative Name(s) |
2-amino-2-deoxyisochorismate synthase. |
ADIC synthase. |
Reaction catalysed |
(2S)-2-amino-4-deoxychorismate + L-glutamate <=> chorismate + L-glutamine |
Cofactor(s) |
Mg(2+).
|
Comment(s) |
- The reaction occurs in the reverse direction to that shown above.
- In contrast to most anthranilate-synthase I (ASI) homologs, this
enzyme is not inhibited by tryptophan.
- In Streptomyces globisporus, the sequential action of this enzyme and
EC 1.3.99.24, 2-amino-4-deoxychorismate dehydrogenase, leads to the
formation of the benzoxazolinate moiety of the enediyne antitumor
antibiotic C-1027.
- In certain Pseudomonads the enzyme participates in the biosynthesis
of phenazine, a precursor for several compounds with antibiotic
activity.
|
Cross-references |
BRENDA | 2.6.1.86 |
EC2PDB | 2.6.1.86 |
ExplorEnz | 2.6.1.86 |
PRIAM enzyme-specific profiles | 2.6.1.86 |
KEGG Ligand Database for Enzyme Nomenclature | 2.6.1.86 |
IUBMB Enzyme Nomenclature | 2.6.1.86 |
IntEnz | 2.6.1.86 |
MEDLINE | Find literature relating to 2.6.1.86 |
MetaCyc | 2.6.1.86 |
UniProtKB/Swiss-Prot |
|
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