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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.6.1.86
| Accepted Name |
|---|
| 2-amino-4-deoxychorismate synthase.
|
| Alternative Name(s) |
|---|
| 2-amino-2-deoxyisochorismate synthase. |
| ADIC synthase. |
| Reaction catalysed |
|---|
| (2S)-2-amino-4-deoxychorismate + L-glutamate <=> chorismate + L-glutamine |
| Cofactor(s) |
|---|
| Mg(2+).
|
| Comment(s) |
|---|
- The reaction occurs in the reverse direction to that shown above.
- In contrast to most anthranilate-synthase I (ASI) homologs, this
enzyme is not inhibited by tryptophan.
- In Streptomyces globisporus, the sequential action of this enzyme and
EC 1.3.99.24, 2-amino-4-deoxychorismate dehydrogenase, leads to the
formation of the benzoxazolinate moiety of the enediyne antitumor
antibiotic C-1027.
- In certain Pseudomonads the enzyme participates in the biosynthesis
of phenazine, a precursor for several compounds with antibiotic
activity.
|
| Cross-references |
|---|
| BRENDA | 2.6.1.86 |
| EC2PDB | 2.6.1.86 |
| ExplorEnz | 2.6.1.86 |
| PRIAM enzyme-specific profiles | 2.6.1.86 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.6.1.86 |
| IUBMB Enzyme Nomenclature | 2.6.1.86 |
| IntEnz | 2.6.1.86 |
| MEDLINE | Find literature relating to 2.6.1.86 |
| MetaCyc | 2.6.1.86 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-