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ENZYME entry: EC 2.6.1.86

Accepted Name
2-amino-4-deoxychorismate synthase.
Alternative Name(s)
2-amino-2-deoxyisochorismate synthase.
ADIC synthase.
Reaction catalysed
(2S)-2-amino-4-deoxychorismate + L-glutamate <=> chorismate + L-glutamine
Cofactor(s)
Mg(2+).
Comment(s)
  • The reaction occurs in the reverse direction to that shown above.
  • In contrast to most anthranilate-synthase I (ASI) homologs, this enzyme is not inhibited by tryptophan.
  • In Streptomyces globisporus, the sequential action of this enzyme and EC 1.3.99.24, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumor antibiotic C-1027.
  • In certain Pseudomonads the enzyme participates in the biosynthesis of phenazine, a precursor for several compounds with antibiotic activity.
Cross-references
BRENDA2.6.1.86
EC2PDB2.6.1.86
ExplorEnz2.6.1.86
PRIAM enzyme-specific profiles2.6.1.86
KEGG Ligand Database for Enzyme Nomenclature2.6.1.86
IUBMB Enzyme Nomenclature2.6.1.86
IntEnz2.6.1.86
MEDLINEFind literature relating to 2.6.1.86
MetaCyc2.6.1.86
Rhea expert-curated reactions2.6.1.86
UniProtKB/Swiss-Prot
Q8GMH4, SGCD_STRGL

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