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ENZYME

ENZYME entry: EC 2.7.1.134

PURL: https://purl.expasy.org/enzyme/EC/2.7.1.134
Accepted Name
inositol-tetrakisphosphate 1-kinase
Alternative Name(s)
1D-myo-inositol-tetrakisphosphate 1-kinase
1D-myo-inositol-trisphosphate 5-kinase
1D-myo-inositol-trisphosphate 6-kinase
inositol-trisphosphate 5-kinase
inositol-trisphosphate 6-kinase
Reaction catalysed
1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)
Comment(s)
  • This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6.
  • The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP.
  • It can also catalyze an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP.
  • The enzymes from animals and plants also have the activity of EC 2.7.1.159.
  • Formerly EC 2.7.1.133 and EC 2.7.1.139.
Cross-references
BRENDA2.7.1.134
EC2PDB2.7.1.134
ExplorEnz2.7.1.134
KEGG Ligand Database for Enzyme Nomenclature2.7.1.134
IUBMB Enzyme Nomenclature2.7.1.134
MEDLINEFind literature relating to 2.7.1.134
MetaCyc2.7.1.134
Rhea expert-curated reactions2.7.1.134
UniProtKB/Swiss-Prot
Q9SBA5, ITPK1_ARATHP0C0T1, ITPK1_BOVINQ5F480, ITPK1_CHICK
Q7ZU91, ITPK1_DANREQ9XYQ1, ITPK1_ENTH1Q13572, ITPK1_HUMAN
Q84Y01, ITPK1_MAIZEQ8BYN3, ITPK1_MOUSEA2Z4C5, ITPK1_ORYSI
Q33BI9, ITPK1_ORYSJA7X657, ITPK1_SOYBNQ7SY78, ITPK1_XENLA
O81893, ITPK2_ARATHB8AJL9, ITPK2_ORYSIQ10PL5, ITPK2_ORYSJ
A7X665, ITPK2_SOYBNQ9SUG3, ITPK3_ARATHB8AR41, ITPK3_ORYSI
Q75GI4, ITPK3_ORYSJA7X672, ITPK3_SOYBNA2X4M8, ITPK4_ORYSI
Q6K7B8, ITPK4_ORYSJA7X680, ITPK4_SOYBNA0JJZ6, ITPK5_ORYSI
Q7XBW0, ITPK5_ORYSJB8BDK0, ITPK6_ORYSIQ0J0B2, ITPK6_ORYSJ

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-