| Accepted Name |
|---|
| inositol-1,3,4-trisphosphate 5/6-kinase.
|
| Alternative Name(s) |
|---|
| inositol trisphosphate 5/6-kinase. |
| Ins(1,3,4)P3 5/6-kinase. |
| IP56K. |
| Reaction catalysed |
|---|
- 1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)
- 1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)
|
| Comment(s) |
|---|
- In humans, this enzyme, along with EC 2.7.1.127, EC 2.7.1.140 and
EC 2.7.1.158 is involved in the production of inositol
hexakisphosphate (InsP6).
- InsP6 is involved in many cellular processes, including mRNA export
from the nucleus.
- Yeast do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by
the actions of EC 2.7.1.151 and EC 2.7.1.158.
- The enzymes from animals and plants also have the activity of
EC 2.7.1.134.
|
| Cross-references |
|---|
| BRENDA | 2.7.1.159 |
| EC2PDB | 2.7.1.159 |
| ExplorEnz | 2.7.1.159 |
| PRIAM enzyme-specific profiles | 2.7.1.159 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.159 |
| IUBMB Enzyme Nomenclature | 2.7.1.159 |
| IntEnz | 2.7.1.159 |
| MEDLINE | Find literature relating to 2.7.1.159 |
| MetaCyc | 2.7.1.159 |
| Rhea expert-curated reactions | 2.7.1.159 |
| UniProtKB/Swiss-Prot |
| Q9SBA5, ITPK1_ARATH; | P0C0T1, ITPK1_BOVIN; | Q5F480, ITPK1_CHICK; |
| Q7ZU91, ITPK1_DANRE; | Q9XYQ1, ITPK1_ENTHI; | Q13572, ITPK1_HUMAN; |
| Q84Y01, ITPK1_MAIZE; | Q8BYN3, ITPK1_MOUSE; | A2Z4C5, ITPK1_ORYSI; |
| Q33BI9, ITPK1_ORYSJ; | Q7SY78, ITPK1_XENLA; | O81893, ITPK2_ARATH; |
| B8AJL9, ITPK2_ORYSI; | Q10PL5, ITPK2_ORYSJ; | Q9SUG3, ITPK3_ARATH; |
| B8AR41, ITPK3_ORYSI; | Q75GI4, ITPK3_ORYSJ; | O80568, ITPK4_ARATH; |
| A2X4M8, ITPK4_ORYSI; | Q6K7B8, ITPK4_ORYSJ; | A0JJZ6, ITPK5_ORYSI; |
| Q7XBW0, ITPK5_ORYSJ; | B8BDK0, ITPK6_ORYSI; | Q0J0B2, ITPK6_ORYSJ; |
|