Expasy logo

ENZYME

ENZYME entry: EC 2.7.1.159

PURL: https://purl.expasy.org/enzyme/EC/2.7.1.159
Accepted Name
inositol-1,3,4-trisphosphate 5/6-kinase
Alternative Name(s)
inositol trisphosphate 5/6-kinase
Ins(1,3,4)P3 5/6-kinase
IP56K
Reaction catalysed
  • 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)
  • 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)
Comment(s)
  • In humans, this enzyme, along with EC 2.7.1.127, EC 2.7.1.140 and EC 2.7.1.158 is involved in the production of inositol hexakisphosphate (InsP6).
  • InsP6 is involved in many cellular processes, including mRNA export from the nucleus.
  • Yeast do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 and EC 2.7.1.158.
  • The enzymes from animals and plants also have the activity of EC 2.7.1.134.
Cross-references
BRENDA2.7.1.159
EC2PDB2.7.1.159
ExplorEnz2.7.1.159
KEGG Ligand Database for Enzyme Nomenclature2.7.1.159
IUBMB Enzyme Nomenclature2.7.1.159
MEDLINEFind literature relating to 2.7.1.159
MetaCyc2.7.1.159
Rhea expert-curated reactions2.7.1.159
UniProtKB/Swiss-Prot
Q9SBA5, ITPK1_ARATHP0C0T1, ITPK1_BOVINQ5F480, ITPK1_CHICK
Q7ZU91, ITPK1_DANREQ9XYQ1, ITPK1_ENTH1Q13572, ITPK1_HUMAN
Q84Y01, ITPK1_MAIZEQ8BYN3, ITPK1_MOUSEA2Z4C5, ITPK1_ORYSI
Q33BI9, ITPK1_ORYSJA7X657, ITPK1_SOYBNQ7SY78, ITPK1_XENLA
O81893, ITPK2_ARATHB8AJL9, ITPK2_ORYSIQ10PL5, ITPK2_ORYSJ
A7X665, ITPK2_SOYBNQ9SUG3, ITPK3_ARATHB8AR41, ITPK3_ORYSI
Q75GI4, ITPK3_ORYSJA7X672, ITPK3_SOYBNO80568, ITPK4_ARATH
A2X4M8, ITPK4_ORYSIQ6K7B8, ITPK4_ORYSJA7X680, ITPK4_SOYBN
A0JJZ6, ITPK5_ORYSIQ7XBW0, ITPK5_ORYSJB8BDK0, ITPK6_ORYSI
Q0J0B2, ITPK6_ORYSJ

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-