ENZYME entry: EC 2.7.1.160
Accepted Name |
2'-phosphotransferase.
|
Alternative Name(s) |
Tpt1p. |
yeast 2'-phosphotransferase. |
Reaction catalysed |
2'-phospho-[ligated tRNA] + NAD(+) <=> ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide |
Comment(s) |
- Catalyzes the final step of tRNA splicing in the yeast Saccharomyces
cerevisiae.
- The reaction takes place in two steps: in the first step,
the 2'-phosphate on the RNA substrate is ADP-ribosylated, causing the
relase of nicotinamide and the formation of the reaction
intermediate, ADP-ribosylated tRNA.
- In the second step, dephosphorylated (mature) tRNA is formed along
with ADP ribose 1'',2''-cyclic phosphate.
- Highly specific for oligonucleotide substrates bearing an internal
2'-phosphate.
- Oligonucleotides with only a terminal 5'- or 3'-phosphate are not
substrates.
|
Cross-references |
BRENDA | 2.7.1.160 |
EC2PDB | 2.7.1.160 |
ExplorEnz | 2.7.1.160 |
PRIAM enzyme-specific profiles | 2.7.1.160 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.160 |
IUBMB Enzyme Nomenclature | 2.7.1.160 |
IntEnz | 2.7.1.160 |
MEDLINE | Find literature relating to 2.7.1.160 |
MetaCyc | 2.7.1.160 |
Rhea expert-curated reactions | 2.7.1.160 |
UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-